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Characterization of the Molybdenum Cofactor of Sulfite Oxidase, Xanthine Oxidase, and Nitrate Reductase
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TheMolybdenum cofactor has been isolated in an oxidized inactive form from purified molybdoenzymes and the isolated material is shown to be a novel pterin.Abstract:
The molybdenum cofactor has been isolated in an oxidized inactive form from purified molybdoenzymes. The isolated material is shown to be a novel pterin. The active cofactor is presumably composed of molybdenum and a reduced form of the pterin.read more
Citations
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Journal ArticleDOI
The History of the Molybdenum Cofactor—A Personal View
TL;DR: This review recalls the history of Moco in a personal view, starting with the genetics and biochemistry in the 1960s and 1970s, followed by Moco biochemistry and the description of its chemical structure in the 1980s, and the elucidation of M Coco biosynthesis in the 1990s and the early 2000s.
Dissertation
Structure-function studies in sulfite oxidase with altered active sites
TL;DR: Structure-Function Studies in Sulfite Oxidase with Altered Active Sites shows that changes in the structure of the molecule’s active sites change with age and changes in its structure also occur with age.
Journal ArticleDOI
Synthesis, Characterization and Chlorination of 4-(Pentyloxy)-7-(prop-2-yn-1-yloxy)pteridin-2-amine
Jevy V. Correia,Carola Schulzke +1 more
TL;DR: In this article , a new alkyne functionalized pterin derivative was synthesized through a reaction of 7-chloropterin with propargyl alcohol in the presence of sodium hydride.
References
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Journal ArticleDOI
Cell biology and molecular basis of denitrification.
TL;DR: Denitrification is intimately related to fundamental cellular processes that include primary and secondary transport, protein translocation, cytochrome c biogenesis, anaerobic gene regulation, metalloprotein assembly, and the biosynthesis of the cofactors molybdopterin and heme D1.
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The Mononuclear Molybdenum Enzymes
TL;DR: It is now well-established that all molybdenum-containing enzymes other than nitrogenase fall into three large and mutually exclusive families, as exemplified by the enzymes xanthine oxidation, sulfite oxidase, and DMSO reductase; these enzymes represent the focus of the present account.
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Cell biology of molybdenum
Ralf R. Mendel,Florian Bittner +1 more
TL;DR: The transition element molybdenum (Mo) is of essential importance for (nearly) all biological systems as it is required by enzymes catalyzing diverse key reactions in the global carbon, sulfur and nitrogen metabolism.
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Molybdoenzymes and molybdenum cofactor in plants
Ralf R. Mendel,Robert Hänsch +1 more
TL;DR: A model for the three-step biosynthesis of Moco involving the complex interaction of six proteins will be described and a putative Moco-storage protein distributing Moco to the apoproteins of Mo-enzymes will be discussed.
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Enzymology of the acetyl-CoA pathway of CO2 fixation.
TL;DR: The remarkable series of enzymatic steps involved in acetyl-CoA formation by this pathway that is a key component of the global carbon cycle is described.