Journal ArticleDOI
Clinical properties of levobupivacaine or racemic bupivacaine for sciatic nerve block.
Andrea Casati,Jacques E. Chelly,Elisa Cerchierini,Roberta Santorsola,Fiorella Nobili,Crispino Grispigni,Pia Di Benedetto,Giorgio Torri +7 more
Reads0
Chats0
TLDR
A dose of 20 mL of 0.5% levobupivacaine induces sciatic nerve block of similar onset, duration, and intensity as the block produced by the same volume and concentration of the racemic solution of bupivacane.About:
This article is published in Journal of Clinical Anesthesia.The article was published on 2002-03-01. It has received 43 citations till now. The article focuses on the topics: Levobupivacaine & Bupivacaine.read more
Citations
More filters
Pharmacology, toxicology, and clinical use of new long acting local anesthetics, ropivacaine and levobupivacaine.
TL;DR: The reduced toxic potential of the two pure left-isomers suggests their use in the clinical situations in which the risk of systemic toxicity related to either overdosing or unintended intravascular injection is high, such as during epidural or peripheral nerve blocks.
Journal ArticleDOI
Bupivacaine, levobupivacaine and ropivacaine: are they clinically different?
Andrea Casati,Marta Putzu +1 more
TL;DR: The reduced toxic potential of the two pure left-isomers supports their use in those clinical situations in which the risk of systemic toxicity related to either overdosing or unwanted intravascular injection is high, such as during epidural or peripheral nerve blocks.
Journal ArticleDOI
Update on local anesthetics: focus on levobupivacaine.
Crina L. Burlacu,Donal J. Buggy +1 more
TL;DR: The pharmacological essentials of the safer profile of levobupivacaine are discussed, the evidence regarding the current clinical indications is analyzed, and the evidence about the equipotency of the two drugs is analyzed.
Journal ArticleDOI
Interscalene brachial plexus anesthesia and analgesia for open shoulder surgery: a randomized, double-blinded comparison between levobupivacaine and ropivacaine.
Andrea Casati,Battista Borghi,Guido Fanelli,Nicoletta Montone,Roberto Rotini,Gianfranco Fraschini,Federico Vinciguerra,G. Torri,Jacques E. Chelly +8 more
TL;DR: This prospective, randomized, double-blinded study demonstrates that 30 mL of levobupivacaine 0.5% induces an interscalene brachial plexus anesthesia of similar onset and intensity as the one produced by the same volume and concentration of ropvacaine.
Journal ArticleDOI
Intraoperative epidural anesthesia and postoperative analgesia with levobupivacaine for major orthopedic surgery: a double-blind, randomized comparison of racemic bupivacaine and ropivacaine ☆
Andrea Casati,Andrea Casati,Roberta Santorsola,Roberta Santorsola,Giorgio Aldegheri,Giorgio Aldegheri,Flavio Ravasi,Flavio Ravasi,Guido Fanelli,Guido Fanelli,Marco Berti,Marco Berti,Gianfranco Fraschini,Gianfranco Fraschini,Giorgio Torri,Giorgio Torri +15 more
TL;DR: Levobupivacaine 0.5% produces an epidural block of similar onset, quality, and duration as the one produced by the same volume of 0.
References
More filters
Journal ArticleDOI
Cardiac arrest following regional anesthesia with etidocaine or bupivacaine
Book
Designing Clinical Research: An Epidemiologic Approach
Stephen B. Hulley,Steven R. Cummings,Warren S. Browner,Deborah Grady,Norman Hearst,Thomas B. Newman +5 more
TL;DR: Basic Ingredients Getting Started: The Anatomy and Physiology of Clinical Research Conceiving the Research Question Choosing the Study Subjects: Specification, Sampling and Recruitment Planning the Measurements: Precision and Accuracy Getting Ready to Estimate Sample Size: Hypotheses and Underlying Principles Estimating Sample Size and Power: The Nitty-gritty Study Designs
Journal ArticleDOI
A comparison of the cardiovascular effects of levobupivacaine and rac-bupivacaine following intravenous administration to healthy volunteers
TL;DR: It has been shown that following i.v. administration levobupivacaine produces significantly less effects on cardiovascular function than does rac-bupvacaine.
Journal ArticleDOI
Cardiovascular and central nervous system effects of intravenous levobupivacaine and bupivacaine in sheep.
TL;DR: Commercially available bupivacaine is an equimolar mixture of R(+)-and S(-)-bupivacane that is currently undergoing preclinical evaluation.
Journal ArticleDOI
Toxicological and local anaesthetic effects of optically active isomers of two local anaesthetic compounds.
TL;DR: Differences in absorption rates between the bupivacaine isomers similar to those demonstrated for the mepivacsine isomers indicate differences in infiltration anaesthesia by L(-)–bupavacaine.