Journal ArticleDOI
Cocaine blockade of the acetylcholine positive inotropic response in ventricular myocardium.
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TLDR
In isolated cat heart preparations, ACh in doses of 10-4 g elicits a positive inotropic response that is blocked by cocaine, which appears to be similar to cocaine blockade of the response to indirect acting amines, e.g., tyramine.Abstract:
SummaryIn isolated cat heart preparations, ACh in doses of 10-4 g elicits a positive inotropic response. This response is blocked by cocaine. It appears that the blockade of the response by cocaine is similar to cocaine blockade of the response to indirect acting amines, e.g., tyramine. This is further evidence that the positive inotropic effect of ACh in ventricular myocardium is mediated by NE release.read more
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Journal ArticleDOI
Effects of intracoronary infusions of acetylcholine and nicotine on the dog heart in vivo.
TL;DR: In anaesthetized dogs intracoronary infusions of high doses of nicotine and acetylcholine increased myocardial contractile force and this could be prevented by pre‐treatment with desmethylimipramine or phenoxybenzamine but this was prevented by atropine.
Journal ArticleDOI
Comparison of the cardiostimulatory effects of acetylcholine and nicotine on the working guinea-pig heart.
TL;DR: The results support the view that the cardiostimulatory effects of acetylcholine are due entirely to endogenous catecholamine release, but that the effects of nicotine may involve an additional action.