Journal ArticleDOI
Correlations between clinical symptoms, leukocyte sensitivity, antigen-binding capacity, and Prausnitz-Küstner activity in a longitudinal study of ragweed pollinosis☆
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TLDR
A decrease in the patient's reaginic antibody titer to ragweed occurred following treatment and persisted after treatment was stopped, and the antibody responsible for antigen-binding activity in this patient was localized to the immunoglobulin G class.About:
This article is published in Journal of Allergy.The article was published on 1970-11-01. It has received 16 citations till now. The article focuses on the topics: Immunoglobulin G & Ragweed.read more
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Journal ArticleDOI
A comparative study of the effectiveness of the Rinkel method and the current standard method of immunotherapy for ragweed pollen hay fever
Thomas E. Van Metre,Thomas E. Van Metre,N. Franklin Adkinson,N. Franklin Adkinson,Frank J. Amodio,Frank J. Amodio,Lawrence M. Lichtenstein,Lawrence M. Lichtenstein,Michael R. Mardiney,Michael R. Mardiney,Philip S. Norman,Philip S. Norman,Gary L. Rosenberg,Gary L. Rosenberg,Anne K. Sobotka,Anne K. Sobotka,M.D. Valentine,M.D. Valentine +17 more
TL;DR: Under the conditions of this study, the current standard method of immunotherapy produced a significant decrease in ragweed hay fever symptom-medication scores, increase in antiragweed IgG levels, and decrease in seasonal rise in antigweed IgE levels in comparison with the effects of either Rinkel method or placebo.
Journal ArticleDOI
A comparison of immunotherapy schedules for injection treatment of ragweed pollen hay fever.
Thomas E. Van Metre,Thomas E. Van Metre,N. Franklin Adkinson,N. Franklin Adkinson,Frank J. Amodio,Frank J. Amodio,Anne Kagey-Sobotka,Anne Kagey-Sobotka,Lawrence M. Lichtenstein,Lawrence M. Lichtenstein,Michael R. Mardiney,Michael R. Mardiney,Philip S. Norman,Philip S. Norman,Gary L. Rosenberg,Gary L. Rosenberg +15 more
TL;DR: Treatment failures on Rinkel immunotherapy respond well to adequate dose immunotherapy by either schedule, and patients after adequate treatment with either RW-Wk or RW-Cl have significantly lower symptom-medication scores than those of the placebo groups and immunologic changes similar toThose of the entire active-treatment group.
Journal ArticleDOI
A controlled study of the effectiveness of the Rinkel method of immunotherapy for ragweed pollen hay fever
Thomas E. Van Metre,Thomas E. Van Metre,N. Franklin Adkinson,N. Franklin Adkinson,Lawrence M. Lichtenstein,Lawrence M. Lichtenstein,Michael R. Mardiney,Michael R. Mardiney,Philip S. Norman,Philip S. Norman,Gary L. Rosenberg,Gary L. Rosenberg,Anne K. Sobotka,Anne K. Sobotka,M.D. Valentine,M.D. Valentine +15 more
TL;DR: Rinkel method immunotherapy with ragweed pollen extract was no more effective than placebo given in an imitation of the Rinkel method, and despite the absence of specific effect on symptom-medication scores and measured immunologic variates, 10 of the 12 ragweed-treated patients were of the opinion that their hay fever symptoms during the rag weed pollen season were less severe in 1978 than in 1977 and that they had been helped by Rinkel process immunotherapy.
Journal ArticleDOI
The Role of Immunotherapy in Cockroach Asthma
TL;DR: It is demonstrated that CRa-IT reduces symptom and medication scores clinically in cockroach-asthmatic subjects, and the CRa -IT produces theCRa-specific blocking antibody of the IgG type.
Journal ArticleDOI
Comparison of Polymerized and Unpolymerized Antigen E for Immunotherapy of Ragweed Allergy
TL;DR: Polymerization of ragweed antigen into high-molecular-weight polymers could improve immunotherapy for ragweed pollinosis by reducing side effects while retaining immunogenicity.
References
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Journal ArticleDOI
Isolation studies of allergens from regweed pollen.
T. P. King,P. S. Norman +1 more
Journal ArticleDOI
Clinical and in vitro studies on the role of immunotherapy in ragweed hay fever
TL;DR: The role of immunotherapy in ragweed hay fever has been investigated by a combination of clinical and laboratory technics and an in vitro model of human allergic reactions: the antigenically induced release of histamine from the isolated leukocytes of sensitive donors.
Clinical and in vitro studies on the role of immunotherapy in ragweed hay fever
TL;DR: The role of immunotherapy in ragweed hay fever has been investigated by a combination of clinical and laboratory technics as mentioned in this paper, where a double blind evaluation of the patient's symptoms was performed in a semiquantitative fashion by patient diary and physician examination.
Journal ArticleDOI
Immunotherapy of pollinosis in children: investigation of the immunologic basis of clinical improvement.
TL;DR: 18 of 35 children were given a preseasonal course of whole ragweed extract and showed a significant decrease in clinical symptomatology (p less than 0.001); 13 of these had fewer symptoms than any of the 17 control patients.
Journal ArticleDOI
Histamine release from leukocytes of hypersensitive individuals: II. Reduced sensitivity of leukocytes after injection therapy
Jacob J. Pruzansky,Roy Patterson +1 more
TL;DR: A progressive increase was observed in the concentration of antigen required to release a significant proportion of the total cellular histamine in ragweed-sensitive patients treated by courses of injections of aqueous ragweed extract.