Journal ArticleDOI
Effect of lactulose on ammonia production in a fecal incubation system.
TLDR
In this article, an in vitro fecal incubation system was used to demonstrate how lactulose influences ammonia metabolism in the colon, and the effect of low pH in reducing generation of ammonia appears to be part of a general reduction in bacterial metabolism.About:
This article is published in Gastroenterology.The article was published on 1978-03-01. It has received 126 citations till now. The article focuses on the topics: Ammonia production & Lactulose.read more
Citations
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Journal ArticleDOI
Colonic health: fermentation and short chain fatty acids.
TL;DR: More human studies are now needed on SCFAs, especially, given the diverse nature of carbohydrate substrates and the SCFA patterns resulting from their fermentation, which will be key to the success of dietary recommendations to maximize colonic disease prevention.
Journal ArticleDOI
Short chain fatty acids in the human colon.
TL;DR: The human colon contains a luxuriant mixed culture of bacteria, which is in the main strictly anaerobic, the end-products being primarily the short chain, or volatile, fatty acids, acetic, propionic, and butyric acid.
Journal Article
Protein degradation in the large intestine: relevance to colorectal cancer.
TL;DR: Recent work has shown that diets high in meat, fat and low in fibre increase human faecal water genotoxicity and it is likely that metabolites from colonic protein metabolism contribute to this increase in genot toxicity during high meat intakes.
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Carbohydrate Digestibility and Metabolic Effects
TL;DR: Further studies are required to explore these important aspects of metabolism related to the rate of carbohydrate absorption and fermentation and their implications in health and disease.
Journal ArticleDOI
Role of pH in production of hydrogen from carbohydrates by colonic bacterial flora. Studies in vivo and in vitro.
J A Perman,S Modler,A C Olson +2 more
TL;DR: The observations indicate that the breath H2 response to malabsorbed carbohydrate is affected by colonic pH, and it appears that the efficiency of bacterial carbohydrate metabolism in the colon is pH dependent.
References
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Microdiffusion Analysis and Volumetric Error
TL;DR: In this article, Microdiffusion analysis and volumetric error was used to detect micro-diffusion errors in the context of micro-scale analysis of the volumetry data.
Journal ArticleDOI
Urea metabolism in man.
TL;DR: In the studies reported herein, labeled urea was administered intravenously to normal subjects and the rate of extrarenal disposal was determined, indicating that 15 to 30 per cent of the urea being synthesized in normal subjects is continually being destroyed.
Journal ArticleDOI
Effects of lactulose and other laxatives on ileal and colonic pH as measured by a radiotelemetry device
TL;DR: Using a pH-sensitive radiotelemetering device the effect of lactulose on luminal pH in the ileum, colon, and rectum has been compared with that of two other laxative agents and it was not possible to produce a significantly more uniform reduction of pH along the length of the colon by combining these laxatives compared with lactulOSE alone.
Journal Article
In vivo dialysis of faeces as a method of stool analysis. i. technique and results in normal subjects.
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Lactulose in the treatment of chronic portal-systemic encephalopathy. A double-blind clinical trial
TL;DR: Long-term administration of lactulose was effective in preventing or ameliorating episodes of PSE despite discontinuing neomycin and doubling the daily protein intake, and no consistent qualitative or quantitative alteration in stool flora was demonstrated.