Effectiveness of anti-tuberculosis chemotherapy in patients with tuberculosis relapse compared with newly diagnosed patients
Dmytro Butov,Mykola Gumenuik,Galyna Gumeniuk,Anton Tkachenko,V. V. Kikinchuk,Ruslan Stepaniuk,Alexandr Peshenko,Tetiana Butova +7 more
TLDR
Standard treatment for patients with NDPTB is considered successful in case of faster health improvement and stabilization, less pronounced rates of toxic adverse reactions to antiTB drugs, faster sputum smear and culture conversion and cavity healing, signs of clinical and radiological convalescence, and the reduced number of large residual changes after the treatment compared with RTB.Abstract:
Background: To study the effectiveness of antituberculosis chemotherapy in patients with relapse pulmonary tuberculosis (RTB) compared with patients with the newly diagnosed process. Methods: We examined 285 TB patients, including 126 individuals with RTB (Group 1) and 159 patients with newly diagnosed pulmonary tuberculosis (NDPTB) (Group 2). All patients were diagnosed with infiltrative PTB. Effectiveness of the basic course of antimycobacterial treatment was assessed in accordance with the following data: time required for the normalization of clinical manifestations, smear conversion, cavity healing, disappearance of infiltrative and focal changes in the pulmonary tissue, as well as the final clinical effectiveness of therapy. Results: Disappearance of clinical symptoms was statistically significantly faster in Group 2 compared with RTB patients in 2.25 ± 0.11 and 3.40 ± 0.15 months, respectively (Pread more
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Treatment effectiveness and outcome in patients with a relapse and newly diagnosed multidrug-resistant pulmonary tuberculosis.
Dmytro Butov,Valeriy Myasoedov,Mykola Gumeniuk,Galyna Gumeniuk,Oleksandra Choporova,Anton Tkachenko,Oleksandra Akymenko,Olena Borysova,Olena Goptsii,Yevhenii Vorobiov,Tetiana Butova +10 more
TL;DR: Standard treatment effectiveness in patients with newly diagnosed MDR-TB manifested by faster improvement and stabilization of health, earlier sputum culture and smear conversion, higher frequency of cavity closure and achievement of certain clinical and radiographic improvement against the background of fewer cases of treatment failure and a higher number of cured patients compared with MDR -TB relapse.
Evaluation of the therapeutic, diagnostic, and prognostic means currently applied to counter the surge of tuberculosis
TL;DR: The patient suffering from a TB infection mounts a humoral immune response that is as important as a cellular immune reactivity and is useful as a prognostic of treatment outcome and as a diagnostic of latent infections.
Proceedings ArticleDOI
Machine Learning Model of COVID-19 Forecasting in Ukraine Based on the Linear Regression
TL;DR: In this paper, the authors categorize forecasting techniques into different types, including stochastic theory mathematical models and data science/machine learning techniques for forecasting the number of future cases.
Journal ArticleDOI
Effectiveness of inhaled hypertonic saline application for sputum induction to improve Mycobacterium tuberculosis identification in patients with pulmonary tuberculosis.
Dmytro Butov,Yurii Feshchenko,Valeriy Myasoedov,Mykhailo Kuzhko,Mykola Gumeniuk,Galyna Gumeniuk,Anton Tkachenko,Nekrasova Nataliya,Olena Borysova,Tetiana Butova +9 more
TL;DR: A prospective, randomized, open, two-arm, comparative study on MTB identification effectiveness when using inhaled sodium chloride hypertonic solution was performed in patients diagnosed with pulmonary tuberculosis (TB) as mentioned in this paper.
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Favorable outcome of individual regimens containing bedaquiline and delamanid in drug-resistant tuberculosis: A systematic review
TL;DR: In this paper , the authors evaluated the effectiveness of individual regimens containing bedaquiline and delamanid on culture conversion and treatment success in patients with drug-resistant tuberculosis (DR-TB).
References
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Book ChapterDOI
T‐Cell Responses and Cytokines
TL;DR: One strategy for developing antituberculosis vaccines is to characterize the T cells and cytokines that mediate clearance of bacilli during the primary immune response as well as the memory T-cell subpopulations and cytokine that protect against tuberculosis from exogenous reinfection and endogenous reactivation.