Journal ArticleDOI
Experimental alveolar lipo-proteinosis following the inhalation of silica
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This article is published in The Journal of Pathology.The article was published on 1970-08-01. It has received 118 citations till now. The article focuses on the topics: Inhalation.read more
Citations
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Journal ArticleDOI
Pulmonary alveolar proteinosis: progress in the first 44 years.
TL;DR: There has been rapid progress toward elucidation of the molecular mechanisms underlying both the congenital and acquired forms of pulmonary alveolar proteinosis, following serendipitous discoveries in gene-targeted mice lacking granulocyte-macrophage colony-stimulating factor.
Journal ArticleDOI
Pulmonary alveolar proteinosis: clinical aspects and current concepts on pathogenesis
TL;DR: There are at least two congenital forms of the disease, several different animal models suggesting that pulmonary alveolar proteinosis is unlikely to be a single disease entity and more likely to represent a clinical syndrome, and the overall prognosis is good.
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Pulmonary alveolar phospholipoproteinosis: experience with 34 cases and a review
TL;DR: Of the 21 patients who underwent therapeutic bronchoalveolar lavage, 13 had no recurrence of the disease during a mean follow-up of 8.8 years, and three deaths occurred among the 34 patients.
Journal ArticleDOI
Pulmonary alveolar proteinosis.
Bruce C. Trapnell,Koh Nakata,Francesco Bonella,Ilaria Campo,Matthias Griese,John A. Hamilton,Tisha Wang,Cliff Morgan,Vincent Cottin,Cormac McCarthy +9 more
TL;DR: Pulmonary alveolar proteinosis comprises a group of diseases with different pathogenetic mechanisms but a common outcome — the progressive accumulation ofAlveolar surfactant in the lungs and dysfunction of alveolars macrophages, which result in respiratory failure and increased risk of secondary infections.
Journal ArticleDOI
The molecular basis of pulmonary alveolar proteinosis.
Brenna Carey,Bruce C. Trapnell +1 more
TL;DR: Pulmonary alveolar proteinosis and related research has uncovered a critical and emerging role for GM-CSF in the regulation of pulmonary surfactant homeostasis, lung host defense, and systemic immunity.
References
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Book
Histochemistry, theoretical and applied
TL;DR: The new Pearse bids fair to become the leader, even amongst so notable a collection of books devoted entirely or largely to histochemical techniques.
Journal ArticleDOI
Pulmonary alveolar proteinosis.
S H Rosen,B Castleman,A A Liebow +2 more
TL;DR: A remarkable disease of the lung that consists of the filling of the alveoli by a PAS-positive proteinaceous material, rich in lipid, appears to be produced by the lining cells, which slough into the lumen, ultimately becoming necrotic and yielding granules and variable laminated bodies to theAlveolar content.
Journal ArticleDOI
Desquamative interstitial pneumonia
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A study of conditions for Kjeldahl determination of nitrogen in proteins; description of methods with mercury as catalyst, and titrimetric and gasometric measurements of the ammonia formed.
TL;DR: The publications on Kjeldahl’s method for determining nitrogen may outnumber those on any other analytical method in the same period of time and the immense usefulness of the method is attributable to its immense usefulness.
Journal ArticleDOI
Alveolar epithelial cell mitochondria as source of the surface-active lung lining.
TL;DR: Findings supporting this hypothesis are the presence of strong surfactant uniquely in the washed mitochondrial fraction of mammalian lung, almost complete loss of mitochondrial lamellar forms accompanying loss of lung surface activity after vagotomy, and the absence of strong surface activity from the lung extracts of animals whose alveolar lining cells show no lameLLar forms.
Related Papers (5)
Alveolar lipo-proteinosis: an ultrastructural comparison of the experimental and human forms.
A. G. Heppleston,A. E. Young +1 more