Patent
Fused pyrimidine derivatives and compositions for treating atherosclerosis containing them
Hermecz Istvan,Meszaros Zoltan,Virag Sandor,Vasvari Lelle,Agnes Horvath,Knoll Jozsef,Sebestyen Gyula,David Agoston +7 more
TLDR
In this article, the compounds are useful in the treatment of atherosclerosis and are disclosed wherein R is hydrogen or C 1 to C 6 alkyl; R 2 and R 3 are each hydrogen or together form a valency bond; R 6 is carboxy or C 2 to C 8 alkoxy carbonyl; and R 7 and R 8 are each Hydrogen atoms or together formed a Valency bond.Abstract:
Compounds of the formula: ##STR1## or pharmaceutically acceptable salts thereof are disclosed wherein R is hydrogen or C 1 to C 6 alkyl; R 2 and R 3 are each hydrogen or together form a valency bond; R 6 is carboxy or C 1 to C 6 alkoxycarbonyl; R 7 and R 8 are each hydrogen or together form a valency bond; R 10 is carboxy or C 1 to C 6 alkoxycarbonyl and the dotted line represents two hydrogen atoms or a valency bond. The compounds are useful in the treatment of atherosclerosis.read more
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Nitrogen bridgehead compounds having anti-allergic effect
Hermecz Istvan,Meszaros Zoltan,Breining Tibor,Virag Sandor,Vasvari Lelle,Horvath Agnes,Nagy Gabor,Attila Mandi,Szuecs Tamas,Bitter Istvan,Sebestyen Gyula +10 more
TL;DR: In this article, the antiallergic and particularly antiasthmatic compounds of the formula: 9-phenylhydrazono-6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido(1,2-a)pyrimidine-3-carboxylic acid are identified.
Patent
Substituted pyrrolo[2,1-b]quinazolines and pyrido[2,1-b]quinazolines useful for the treatment of or the prevention of gastrointestinal ulcers
TL;DR: Substituted Pyrrolo and Pyrido are provided in this article for the treatment of or prevention of the formation of gastrointestinal ulcers, and pharmaceutical compositions containing them are provided.
Patent
Process for the preparation of derivatives of pyrrolidine and piperidine
TL;DR: Processes and intermediates for the preparation of the antiarrhythmic agent 2,5-bis(2,2, 2-trifluoroethoxy)-N-(2-piperidylmethyl)benzamide are described in this article.
Patent
Antiallergic nitrogen bridge-head compounds
Hermecz Istvan,Meszaros Zoltan,István Bitter,Breining Tibor,Vasvari Lelle,Agnes Horvath,Nagy Gabor,Attila Mandi,Horvath Agnes,István Bitter,Sebestyen Gyula +10 more
TL;DR: In this paper, antiallergic and antiasthmatic compounds of the formula "STR1" of which 9-phenylamino-6-methyl-4-oxo-6,7-dihydro-4H-pyrido(1,2-a)pyrimidine-3-carboxylic acid and optically active antipodes and salts thereof are examples are examples.
Patent
Condensed cycloaliphatic derivatives of substituted pyrido[1,2-a]pyrimidines and methods of treating allergic conditions, peptic ulcers and inhibiting gastric acid secretion with them
TL;DR: In this paper, the authors define a group of formula (n is 1 or 2) where n represents a hydrogen or a halogen atom, a C 1 -C 4 alkyl group, a --CN group or a --CONH 2 group, and a --COOR 8 group.
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Patent
1,6,7,8-tetrahydro-4-oxo-4h-pyrido (1,2-a) pyrimidine-9-carboalkoxy compounds
TL;DR: In this paper, the structure or a pharmaceutically acceptable salt thereof of a compound having useful antidepressant activity is defined, where R 1 is alkyl or aryl; R 2 is hydrogen or alkyls; R 3 is halogen, halogen or trifluoromethyl groups.
Patent
Pharmaceutical compositions containing homopyrimidazole derivatives
TL;DR: Analgesic and antipyretic 3-carbalkoxy or 3-carbethoxy-6,7,8,9tetrahydro-4H-pyrido (1,2a) pyrimidin-4-ones which also have a narcosis potentiating effect.