To the Editor— The therapy for Hallopeau's acrodermatitis (continua, perstans), which includes the use of common topical antipsoriatic agents like tar, cignolin, and corticosteroids, is mentioned in literature, but the extreme resistance of the disease to any therapy is well known The systemic use of cytostatic agents (methotrexate) has been described with good results in this disease, but it carries all the inevitable risks of a long-term treatment 1 Topical use of methotrexate soaks under occlusion, which have been used alternately with betamethasone valerate, has been found to have beneficial results in the treatment of relapsing pustular eruption of the hands and feet 2 We could not find a report of the topical use of a cytostatic agent in the treatment of Hallopeau's acrodermatitis Topical application of mechlorethamine hydrochloride (a nitrogen mustard) has been found to be useful in psoriasis 3 We decided to treat a patient with Hallopeau's acrodermatitis with

[Hallopeau's continuous suppurative acrodermatitis. Treatment with methotrexate].

Treatment of Hallopeau's acrodermatitis with topical mechlorethamine.

Acrodermatitis continua (Hallopeau's acrodermatitis) is a rare and distinctive variant of pustular

Mutilating Acrodermatitis Continua (Hallopeau's Acrodermatitis)

Acrodermatitis continua of Hallopeau is a sterile pustular dermatosis primarily of the digits. Often considered a type of pustular psoriasis, it may be difficult to diagnose and even more difficult to treat. Initial involvement of a distal finger or toe may appear as erythema which should not be confused with the chilblains-like findings potentially associated with COVID-19 infection. We review the clinical manifestations of and explore potential therapeutic options for this uncommon, clinically striking dermatosis.

[Hallopeau's continuous suppurative acrodermatitis. Treatment with methotrexate].

Citations

Treatment of Hallopeau's acrodermatitis with topical mechlorethamine.

Mutilating Acrodermatitis Continua (Hallopeau's Acrodermatitis)

Acrodermatitis continua of Hallopeau: historical perspectives and modern management.