Journal ArticleDOI
Histopathology and cytogenetics of tumors induced by the application of 7, 12-dimethylbenz[a]anthracene (DMBA) in mouse cervix
M.G. Joneja,D.B. Coulson +1 more
TLDR
DMBA ( 7,12 -dimethylbenz[a]anthracene)-coated threads were placed in the vaginal fornix of 4–5 week-old ICR mice and a wide range of karyotypic composition was revealed, including a heterogeneous cell population with a majority of the metaphase plates containing four metacentric chromosomes.About:
This article is published in European Journal of Cancer.The article was published on 1973-05-01. It has received 4 citations till now. The article focuses on the topics: Squamous carcinoma & 7,12-Dimethylbenz[a]anthracene.read more
Citations
More filters
Journal ArticleDOI
A look beyond the priority: A systematic review of the genotoxic, mutagenic, and carcinogenic endpoints of non-priority PAHs.
Francisco Carlos da Silva Junior,Maria Beatriz Mesquita Cansanção Felipe,Denis Elvis Farias de Castro,Sinara Carla da Silva Araújo,Herbert Costa Nóbrega Sisenando,Silvia Regina Batistuzzo de Medeiros +5 more
TL;DR: In this article, a systematic review of in vitro, in vivo, and in silico studies to assess the genotoxicity, mutagenicity, and carcinogenicity of 13 US - EPA non-priority PAHs present in the environment was conducted.
Book ChapterDOI
Animal Models for Tumors of the Ovary and Uterus
TL;DR: The ultimate objective of animal studies of cancer is to achieve a better understanding of factors responsible for human disease in the hope that this may be ultimately eliminated or controlled.
Journal ArticleDOI
Autoradiographic studies of experimentally induced atypias in the cervical epithelium of mice.
C. A. Rubio,Bengt Lagerlöf +1 more
TL;DR: The autoradiographic pattern of the cervix epithelium after iterated application of the carcinogen 3,4-benzpyrene was investigated in 100 C57B1 mice and the labelling of superficial cells in moderate atypias suggests that, despite cytoplasmic maturation, their nuclei retained the property of less mature or of undifferentiated cells.
References
More filters
Journal ArticleDOI
Chromosome studies on normal and leukemic human leukocytes.
Journal ArticleDOI
The effects of carcinogenic chemicals in newborn mice.
Journal Article
Cytogenetic studies on rat leukemia induced by pulse doses of 7,12-dimethylbenz(alpha)anthracene.
TL;DR: Cytogenetic studies were carried out on bone marrow and spleen cells of 40 rats of Long-Evans strain with primary leukemia induced by pulse doses of 7,12-dimethylbenz(α)anthracene, finding consistent chromosomal abnormalities, believed to be the first so far reported for an experimental leukemia.
Journal ArticleDOI
Cytogenetic abnormalities in carcinoma-in-situ and dysplasias of the uterine cervix.
TL;DR: In view of the striking chromosomal abnormalities found in the cells of human carcinoma, it is of the greatest interest to know at what stage they arise, and some observations are presented in this paper.