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Mangosteen total xanthone extract and application thereof in preparation of TR3 receptor inducer

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TLDR
The invention discovers and develops compounds for selectively controlling the TR3 expression approach or medicine compositions with the advanced treating characteristic and has practical meaning.
Abstract
The invention discloses a mangosteen total xanthone extract and a preparation method thereof and well as application in the preparation of a TR3 receptor inducer, belonging to the field of pharmaceuticals and foods. The mangosteen total xanthone extract is applied to preparing foods or medicines for preventing or treating cancers, hepatitis or atherosclerosis as the TR3 receptor inducer. The TR3 receptor inducer and pharmaceutically-acceptable vectors are mixed to prepare powders, tablets, capsules, pills, suppositories, dropping pills, enteric-coated agents, injections, syrups, emulsions, suspensions, tinctures, ointments or sprays. Based on a mechanism that TR3 is possible to be an ideal molecular target for screening anti-tumor and cardiovascular medicines, the invention discovers and develops compounds for selectively controlling the TR3 expression approach or medicine compositions with the advanced treating characteristic and has practical meaning.

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References
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Journal ArticleDOI

Evaluation of the antifungal activity of natural xanthones from Garcinia mangostana and their synthetic derivatives.

TL;DR: The antifungal activity of several xanthones isolated from the fruit hulls of Garcinia mangostana and some derivatives of mangostin against three phytopathogenic fungi has been evaluated.
Journal ArticleDOI

Cytotoxic prenylated xanthones from the young fruit of Garcinia mangostana.

TL;DR: Among the isolates, alpha-mangostin (12), the major metabolite, exhibited the most potent effects against the BC-1 cells, an activity greater than that of the standard drug ellipticine (IC50 = 1.46 microg/ml), while gartanin (10) displayed the strongest activity against the NCI-H187 cells at the respective IC50 values.
Journal ArticleDOI

Xanthones with neuraminidase inhibitory activity from the seedcases of Garcinia mangostana.

TL;DR: Interestingly, structure-activity studies reveal that these xanthones show different kinetic inhibition mechanisms depending upon the arrangement of hydroxyl groups in the B ring.

Screening of xanthone from mangosteen (Garcinia mangostana L.) peels and their effect on cytochrome c reductase and phosphomolybdenum activity

A. S. Zarena, +1 more
TL;DR: In this article, the xanthones in the acetone, ethyl acetate and hexane extract, were investigated by means of high performance liquid chromatography-electrospray ionisation/mass spectrometry (HPLC-ESI/MS) technique.