Patent
Methods for forming regional tissue adherent barriers and drug delivery systems
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TLDR
In this article, a method for forming hydrogel barriers in situ that adhere to tissue and prevent the formation of post-surgical adhesions or deliver drugs or other therapeutic agents to a body cavity is described.Abstract:
Methods are provided for forming hydrogel barriers in situ that adhere to tissue and prevent the formation of post-surgical adhesions or deliver drugs or other therapeutic agents to a body cavity. The hydrogels are cross-linked, resorb or degrade over a period of time, and may be formed by free radical polymerization initiated by a redox system or thermal initiation, or electrophilic-neutrophilic mechanism, wherein two components of an initiating sytem are simultaneously or sequentially poured into a body cavity to obtain widespread dispersal and coating of all or most visceral organs within that cavity prior to gelation and polymerization of the regional barrier. The hydrogel materials are selected to have a low stress at break in tension or torsion, and so as to have a close to equilibrium hydration level when formed.read more
Citations
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References
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Journal ArticleDOI
Bioerodible hydrogels based on photopolymerized poly(ethylene glycol)-co-poly(.alpha.-hydroxy acid) diacrylate macromers
TL;DR: The amphiphilic nature of the macromers causes them to assume a micellar conformation, which enables them to undergo rapid photopolymerization, resulting in the formation of crosslinked gels.
PatentDOI
Gels for encapsulation of biological materials
Jeffrey A. Hubbell,Chandrashekhar P. Pathak,Amarpreet S. Sawhney,Neil P. Desai,Hill Jennifer L,Syed F. A. Hossainy +5 more
TL;DR: Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active materials as discussed by the authors.
PatentDOI
Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
Jeffrey A. Hubbell,Chandrashekhar P. Pathak,Amarpreet S. Sawhney,Neil P. Desai,Hill Jennifer L +4 more
TL;DR: In this paper, the authors described a crosslinked macromer consisting of hydrophilic oligomers having biodegradable monomeric or oligomeric extensions, which are terminated on free ends with end cap monomers or oligomers capable of polymerization and cross linking.
Patent
Crosslinked polymer compositions and methods for their use
TL;DR: Crosslinked polymer compositions as discussed by the authors are a mixture of a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second one containing multiple electrophilic groups, such as succinimidyl groups.
Book
Biodegradable Hydrogels for Drug Delivery
Kalpana R. Kamath,Kinam Park +1 more
TL;DR: Different types of biodegradable hydrogel systems, mechanisms and factors affecting their degradation, and their applications in drug delivery are described and their potential for future applications are described.