Patent
N-(4-piperidinyl) (dihydrobenzofuran or dihydro-2h-benzopyran) carboxamide derivatives
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Piperidine derivatives of formula (SEE FORMULA) wherein A is a radical of formula -CH 2-CH2- (a-1) to (a)-3) may be replaced by a C 1-6alkyl radical as mentioned in this paper.Abstract:
Piperidine derivatives of formula (SEE FORMULA) wherein A is a radical of formula -CH2-CH2- (a-1), -CH2-CH2-CH2- (a-2), or -CH2-CH2-CH2-CH2- (a-3), wherein one or two hydrogen atoms in said radicals (a-1) to (a-3) may be replaced by a C1-6alkyl radical; R1 is hydrogen or halo; R2 is hydrogen, amino, mono or di(C1-6alkyl)amino or C1-6alkylcarbonylamino; R3 is hydrogen or C1-6alkyl; L is C3-6cycloalkyl, C5-6cycloalkanone, C3-6alkenyl optionally substituted with aryl, or L is a radical of formula -Alk-R4 (b-1), -Alk-X-R5 (b-2), -Alk-Y-C(=O)-R7 (b-3), or -Alk-Y-C(=O)NR9R10 (b-4), the N-oxide foams, addition salts and stereochemically isomeric form thereof, said compounds having gastrointestinal motility stimulating properties pharmaceutical compositions containing these compounds as active ingredient, and a method of preparing said compounds and pharmaceutical compositions.read more
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Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives
TL;DR: Novel N-(3-hydroxy-4-piperidinyl)benzamides and derivatives thereof are useful as stimulators of the motility of the gastro-intestinal system.
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Carboxamides useful as antiemetic or antipsychotic agents
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TL;DR: Carboxamides represented by the formula (I): Z represents the carbon atoms necessary to complete a 5- to 7-membered ring, R 1, R 2, and R 3 may be the same or different and are selected from the group consisting of a hydrogen atom, a lower alkyl group, a cycloalkyl group, an amino group, lower al-kylamino groups, an alkoxy group and a nitro group; and A represents an aminoalkyl moiety and acid addition salts thereof as discussed by the authors.
Patent
N-(3-hydroxy-4-piperidinyl) dihydrobenzofuran, (dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
TL;DR: N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydronzodioxin)carboxamide derivatives, their Noxide forms and pharmaceutically acceptable salts having gastrointestinal motility stimulating properties, compositions containing these compounds as active ingredient and methods of treating warm-blooded animals suffering from the decreased peristalsis of the gastrointestinal system as discussed by the authors.
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Azabicycloalkyl benzamide and anilide derivatives
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Benzofurancarboxamides, process for their preparation and pharmaceutical preparations containing them
Daniel Lednicer,Jung-Hui Sun +1 more
TL;DR: In this paper, the atoms necessary to complete a benzo[b]furan or a dihydrobenzo [b]-furan ring are represented by the formula (I) : Z represents the atoms required to complete the ring; R 1, R 2 and R 3 may be the same or different and represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a sulfonamido group having up to six carbon atoms; and A represents a tertiary aminoalkyl group containing the atomic sequence of the same.