Patent
New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same
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TLDR
In this article, a compound of the formula : lower alkyl is substituted with a substituent selected from the group consisting of acyl, hydroxy, lower alkoxy, aryl, lower alkoxy, and a group of the formulas in which R 5 is hydrogen or acyl and R 6 is a hyocyclic group with the attached nitrogen atom.Abstract:
A compound of the formula :
wherein R 1 is lower alkyl optionally substituted with a substituent selected from the group consisting of acyl,hydroxy, lower alkoxy, aryl, lower alkylthio and a group of the formula :
in which R 5 is hydrogen or acyl and
R 6 is hydrogen or lower alkyl; aryl; or amino optionally substituted with substituent(s) selected from the group consisting of lower alkyl and acyl; and R 2 is hydrogen or lower alkyl; or R 1 and R 2 are taken together with the attached nitrogen atom to form a heterocyclic group optionally substituted with substituent(s) selected from the group consisting of lower alkyl, hydroxy(lower)alkyl, lower alkoxy(lower)alkyl, acyl(lower)alkyl, oxo and acyl; R 3 is hydrogen or lower alkyl; and R 4 is lower alkyl; and its pharmaceutically acceptable salt, processes for the preparation thereof and pharmaceutical composition comprising the same.read more
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Renin-inhibitory peptides
James Perry Hudspeth,James Stanley Kaltenbronn,Joseph Thomas Repine,Roark William Howard,Michael Andrew Stier +4 more
TL;DR: In this article, novel renin-inhibitory peptides of the formula ACYL - X - Y - W - U which are useful for the manufacture of pharmaceuticals for treating renin associated hypertension, hyperaldosteronism, and congestive heart failure are described.