Book ChapterDOI
Osteopetroses and Hyperostoses, Hyperphosphatasia and Hypophosphatasia, Fibrous Dysplasia, Fibrogenesis Imperfecta Ossium
Roger Smith
- pp 253-273
TLDR
This chapter discusses osteopetroses and hyperostoses, hyperph phosphatasia and hypophosphatasia, fibrous Dysplasia, and fibrogenesis imperfecta ossium.Abstract:
This chapter discusses osteopetroses and hyperostoses, hyperphosphatasia and hypophosphatasia, fibrous Dysplasia, and fibrogenesis imperfecta ossium. There are a number of separate conditions characterized by varying combinations of excessive amounts of mineralized bone and defects of bone modeling. These may be called osteopetroses or osteoscleroses, and the names are to some extent interchangeable. According to Beighton, Horan, and Hamersma the osteopetroses may be divided into the osteoscleroses, the craniotubular dysplasias, the craniotubular hyperostosis, and miscellaneous conditions. The commonly used name for hyperphosphatasia disorder is derived from the very high level of plasma alkaline phosphatase. In hypophosphatasia condition two biochemical changes can be demonstrated —a reduction in circulating alkaline phosphatase and an increase in urinary phosphoethanolamine.read more
Citations
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Journal Article
Bone resorption restored in osteopetrotic mice by transplants of normal bone marrow and spleen cells : Osteopetrosis
TL;DR: This paper showed that mice with inherited osteopetrosis can recover bone and calcified cartilage by intravenous administration of cell suspensions prepared from spleen and bone marrow of normal littermates.
References
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Journal ArticleDOI
The Natural History of Fibrous Dysplasia: An Orthopaedic, Pathological, and Roentgenographic Study
TL;DR: A long-term follow-up study of thirty-seven cases of polyostotic fibrous dysplasia and thirteen cases of monostotics shows that sarcoma developed after radiation of a lesion in three patients.
Journal Article
Bone resorption restored in osteopetrotic mice by transplants of normal bone marrow and spleen cells : Osteopetrosis
TL;DR: This paper showed that mice with inherited osteopetrosis can recover bone and calcified cartilage by intravenous administration of cell suspensions prepared from spleen and bone marrow of normal littermates.
Journal ArticleDOI
Bone resorption restored in osteopetrotic mice by transplants of normal bone marrow and spleen cells
TL;DR: Capacity to resorb bone and calcified cartilage was restored permanently in mice with inherited osteopetrosis by the intravenous administration of cell suspensions prepared from spleen and bone marrow of normal littermates.
Journal ArticleDOI
Inorganic pyrophosphate in plasma in normal persons and in patients with hypophosphatasia, osteogenesis imperfecta, and other disorders of bone
TL;DR: The excess of PP(1) in plasma might be the cause of the defective mineralization in hypophosphatasia and the function of alkaline phosphatase in bone may be to act as a pyrophosphatase at sites of calcium deposition.
Journal ArticleDOI
The actions of parathyroid hormone on bone: relation to bone remodeling and turnover, calcium homeostasis, and metabolic bone disease. Part IV of IV parts: The state of the bones in uremic hyperaparathyroidism--the mechanisms of skeletal resistance to PTH in renal failure and pseudohypoparathyroidism and the role of PTH in osteoporosis, osteopetrosis, and osteofluorosis.
TL;DR: Kinetic and morphologic studies in patients with parathyroid disease, and a wide variety of studies in experimental animals indicate that one major effect of PTH is to increase the proliferation of osteoprogenitor cells into osteoclasts and so to increase bone turnover.