Journal ArticleDOI
PATHOGENESIS OF CIRCULATORY FAILURE IN ROCKY MOUNTAIN SPOTTED FEVER: Alterations in the Blood Volume and the Thiocyanate Space at Various Stages of the Disease
TLDR
The present studies were undertaken to determine whether the blood volume is altered, to observe the time at which the changes develop and to correlate the magnitude of the alterations with the clinical picture and other pertinent laboratory data.Abstract:
PERIPHERAL circulatory failure is an important complication of Rocky Mountain spotted fever. Previous studies have shown that the collapse occurs usually in the second week of rash and that the disturbance can be alleviated by the administration of preformed protein. 1 The mechanism responsible for the circulatory changes is obscure, but the peripheral collapse is accompanied with a drop in serum proteins and with the development of visible generalized edema. 2 The resemblance of the clinical picture to "shock" suggests that a drop in the circulating blood volume occurs. The present studies were undertaken to determine whether the blood volume is altered, to observe the time at which the changes develop and to correlate the magnitude of the alterations with the clinical picture and other pertinent laboratory data. Determinations of the plasma volume and the thiocyanate space were done serially in a group of patients with rickettsial spotted fever,read more
Citations
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Journal ArticleDOI
Rocky Mountain spotted fever.
TL;DR: Because there is no vaccine available against RMSF, avoidance of tick-infested areas is still the best way to prevent the infection.
Journal ArticleDOI
Identification of the target cells of Orientia tsutsugamushi in human cases of scrub typhus
TL;DR: Rickettsiae were located in endothelial cells in all of the organs evaluated, namely heart, lung, brain, kidney, pancreas, and skin, and within cardiac muscle cells and in macrophages located in liver and spleen.
Journal ArticleDOI
Pathogenic mechanisms of diseases caused by Rickettsia
TL;DR: It is determined that hemostatic mechanisms largely prevent major hemorrhage without disseminated intravascular coagulation or thrombosis‐mediated ischemia, and knowledge of the importance of injury mediated by ROS, phospholipase A2, protease(s) or other mechanisms in vivo is lacking.
Journal ArticleDOI
Rocky Mountain spotted fever: a disease in need of microbiological concern.
TL;DR: Research microbiologists who tackle these challenging organisms have an array of questions to address regarding rickettsial surface composition, structure-function analysis, and pathogenic and immune mechanisms, as well as laboratory diagnosis.
Journal ArticleDOI
Rocky Mountain Spotted Fever: A Seasonal Alert
TL;DR: The clinical diagnosis, which is difficult, is rarely assisted by laboratory findings because antibodies are usually detected only in convalescence, and immunohistologic methods for detection of rickettsiae are unavailable in most clinics.
References
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Journal ArticleDOI
Chemical, clinical, and immunological studies on the products of human plasma fractionation. i. the characterization of the protein fractions of human plasma
TL;DR: In the case of the products from human plasma, it seemed most appropriate to employ not only clinical but also physical chemical methods of control-procedures which had been of value in the development of these products.
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Clinical studies of the blood volume. iv. adaptation of the method to the photoelectric microcolorimeter
TL;DR: The adaptation of the plasma volume method of Gibson and Evans to the photoelectric microcolorimeter of Evelyn and Cipriani has been accomplished without the introduction of any essential change in the technique, and with no sacrifice of accuracy, or restriction of the range of applicability of the method.
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The excretion of chlorids and water and the renal function in serum disease
TL;DR: It was shown by one of us that repeated injections of foreign protein in sensitized animals may lead to damage of the kidney, as well as to the other organs, and it seemed important to determine whether the edema, which is often general in serum disease, is associated with this illness.
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The treatment of rocky mountain spotted fever: with particular reference to intravenous fluids a new approach to basic supportive therapy
TL;DR: Supportive therapy has not been as effectively used in Rocky Mountain spotted fever as it might be because parenteral therapy has been given to poor advantage in some cases and statements such as the following have been made.
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Para-aminobenzoic acid therapy of Rocky Mountain spotted fever; outline of a comprehensive plan of treatment with report of five cases.
TL;DR: The name Rocky Mountain spotted fever is now obviously geographically incorrect, since this disease has been found in forty-seven of the forty-eight states, and its incidence and importance to public health in the United States are shown.