Preparation method of S-2-(4-methoxyphenoxy) sodium propionate

TLDR: In this paper, a preparation method of S-2-(4-methoxyphenoxy) sodium propionate serving as a high optically-active sweet inhibitor was presented.

Abstract: The invention discloses a preparation method of S-2-(4-methoxyphenoxy) sodium propionate serving as a high optically-active sweet inhibitor. The preparation method comprises the steps of reacting D-substituted lactate with substituted benzene sulfonyl chloride to generate a corresponding R-substituted sulfonyl lactate; then reacting the obtained R-substituted sulfonyl lactate with p-methoxy phenate in a solvent to generate S-2-(4-methoxyphenoxy) propionate; and hydrolyzing and acidifying the obtained ester, and then reacting with an alkali containing sodium ions, thus obtaining the S-2-(4-methoxyphenoxy) sodium propionate. The preparation method of the S-2-(4-methoxyphenoxy) sodium propionate is developed for the first time. The obtained S-2-(4-methoxyphenoxy) sodium propionate has high optical purity; and when being measured by a sense method, the S-2-(4-methoxyphenoxy) sodium propionate has a better sweet inhibiting effect on sucrose compared with raceme, and can reduce the metabolic burden of R-type non-active ingredients of the raceme in human bodies and eliminate potential harm to the human bodies.