Preparation of stable crystal of salt of ceftizoxime

TLDR: In this paper, an aqueous solution of a salt (e.g., Na or K) of ceftizoxime shown by the formula and isopropyl alcohol are sterilely filtered and mixed and separating out crystal of dihydrate of the salt by filtration.

Abstract: PURPOSE:To obtain crystal of a salt of ceftizoxime useful as an injection for preparation in use, having high stability and improved quickly dissolving properties, by mixing an aqueous solution of the salt of ceftizoxime with isopropyl alcohol, filtering separating out crystal and drying it. CONSTITUTION:An aqueous solution of a salt (e.g., Na or K) of ceftizomixe shown by the formula and isopropyl alcohol are sterilely filtered and mixed and separating out crystal of dihydrate of ceftizomixe is collected by filtration. The crystal is suspended in isopropyl alcohol to give a suspension, which is dividedly added to vials and dried under vacuum, to give anhydrous crystal. The concentration of the aqueous solution of the salt of ceftizomixe is about 30-50W/V%, and the blending ratio of the aqueous solution and the alcohol is about 1:3. Crystal of the salt of ceftizoxime containing neither admixture nor amorphous crystal is obtained, and reduction in titer of the anhydrous crystal is not observed even by allowing it to stand at 50 deg.C for three months.