Primary care: balancing health needs, services and technology
TLDR
It was found that the combined use of L-dopa potentiated the radiation cytotoxicity to HMV-I human melanoma cells, compared with the response seen in non-melanoma HeLa S3 cells.Abstract:
Since L-dopa (L-3,4-dihydroxyphenylalanine) has been shown to possess a selective toxicity for melanoma cells both in vitro and in vivo, we have examined the combined effect of L-dopa and radiation on human melanoma cells. It was found that the combined use of L-dopa potentiated the radiation cytotoxicity to HMV-I human melanoma cells, compared with the response seen in non-melanoma HeLa S3 cells. In HMV-I cells during their exponential phase, L-dopa decreased the shoulder width of the radiation survival curve significantly. In addition, L-dopa significantly inhibited the repair of potentially lethal damage (PLD) in HMV-I cells during their plateau phase. When the distributions of the G,, S, and G2-M cells were measured 24 h after combined L-dopa and radiation treatment, there was significant increase in the accumulation of cells in the G2-M phase of the cell cycle, compared to cells that received either L-dopa or radiation treatment only.read more
Citations
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References
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Inherent cellular radiosensitivity as a basic concept for human tumor radiotherapy
TL;DR: Using the linear quadratic (L-Q) model, a correlation is found between the 95% tumor control dose and the mean surviving fraction at 2 Gy for a given cell type, which suggests that the moderate radiocurability of certain tumors can be partially explained by the intrinsic radiosensitivity of relevant tumor cells.
Journal Article
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TL;DR: Survival determinations made as a function of time between two fractionated UV doses of 100 + 100 ergs/sq mm indicated that these melanoma cells possessed ability to recover from sublethal UV damage.
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TL;DR: A clinical trial of radiation therapy using high individual‐dose‐fractionation schedules resulted in the existence of a large shoulder on the radiation survival curve of cultured mouse and human malignant melanoma cells.
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TL;DR: A new method of analysing DNA distributions of asynchronously growing or mildly perturbed cells is presented, which exceeds the accuracy of other methods and can be used on a large desk calculator or mini‐computer.
Journal ArticleDOI
L-dopa: selective toxicity for melanoma cells in vitro
TL;DR: There was a correlation between toxicity and the extent of incorporation of radioactively labeled L-dopa by each line.