Statistical survey of “saturation analysis” calibration curve data for prednisolone, prednisone and digoxin
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TLDR
An extensive survey of radioimmunoassay calibration data for prednisolone, prednisone and digoxin indicated that the common practice of preparing calibration curves with individual subject's pre-dose plasma or serum, and using this to estimate unknown concentrations for the same subject, is not supported by statistical considerations.About:
This article is published in Steroids.The article was published on 1976-09-01 and is currently open access. It has received 8 citations till now. The article focuses on the topics: Calibration curve & Calibration (statistics).read more
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Journal ArticleDOI
Pharmacokinetics and bioavailability of prednisone and prednisolone in healthy volunteers and patients: A review
TL;DR: This article attempts to comprehensively review these studies categorized under the following four sections: bioavailability; pharmacokinetics; protein binding; analytical methods; and the literature is reviewed through August 1979.
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Kinetics and Dynamics of Prednisolone
TL;DR: Factors which modulate the kinetics and dynamics of prednisone/prednisolone, the most commonly prescribed synthetic glucocorticosteroids in clinical practice, are examined.
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Bioavailability of prednisolone tablets
TL;DR: It is concluded that the average plasma concentrations of prednisolone are superimposable in a statistical sense and that the tablets tested are bioequivalent.
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Effect of Food on the Bioavailability of Prednisone
Aubrey V. Tembo,B S Ermelinda Sakmar,Margarette R. Hallmark,Donald J. Weidler,John G. Wagner +4 more
TL;DR: Two commercial prednisone tablets were studied which had previously been shown to have the slowest and fastest in vitro rates of dissolution and rise to peak plasma prednisolone concentrations in human beings and the effect of food on the adsorption of these two tablets was studied.
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Sensitive radioimmunoassay for digoxin in plasma and urine
TL;DR: A reproducible and sensitive radioimmunoassay for digoxin in either serum, plasma or urine is described and it has been reported that the 12 hr serum digoxin levels, after single 0.5 mg doses, are, in most subjects, below the sensitivity limit of the assay.
References
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A Radioimmunoassay for Cortisol in Plasma and Urine
TL;DR: Antibodies raised against cortisol-21-hemisuccinate conjugated to bovine serum albumin had a high affinity for cortisol, making this method particularly useful for measurement of 24-hr urine free cortisol.
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Statistical characterization of the random errors in the radioimmunoassay dose--response variable.
TL;DR: Practical methods for evaluating the magnitude of the random errors in radioimmunoassay dose--response variables, and the relationship between this error and position on the dose-- response curve are developed.
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Simple method for the determination of plasma corticoids.
TL;DR: A simple dialysis method of estimating cortisol and corticosterone in human plasma using the steroid-binding properties of plasma, which was affected neither by hemolysis nor by drugs which interfered with other methods.
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Radioimmunoassay for prednisolone.
W.A. Colburn,R.H. Buller +1 more
TL;DR: This capability, aside from the greater sensitivity, precision and accuracy offered by this method, provides a distinct advantage in the analysis of large numbers of samples which are required in bioavailability studies.