Patent
Steroid fatty emulsion
Reads0
Chats0
TLDR
In this article, the authors proposed a method to obtain a high anti-inflammatory activity even in a small dose without side effects by using a fatty emulsion containing a steroid having an anti- inflammatory activity selected from stearates and myristates.Abstract:
PURPOSE: A steroid pharmaceutical, containing a steroid having an anti-inflammatory activity as an active constituent, and preferably soybean oil, a phospholipid and water, in the form of a fatty emulsion, and capable of exhibiting a high anti- inflammatory activity even in a small dose without side effects. CONSTITUTION: A steroid fatty emulsion containing a steroid having an anti- inflammatory activity selected from stearates and myristates of dexamethasone, hydrocortisone and prednisone. A preferred pharmaceutical contains 5W50W/V% soybean oil, a phospholipid in an amount to give a weight ratio between the soybean oil and the phospholipid of 100:1W50 and a suitable amount of water. An isotonizing agent, emulsifying assistant, emulsion stabilizer, etc. may be added to the pharmaceutical if necessary. The resultant fatty emulsion is preferably administered parenterally, more preferably intravenously, and exhibits a high and lasting anti- inflammatory activity even in a small dose. COPYRIGHT: (C)1982,JPO&Japioread more
Citations
More filters
Patent
Method of preparing controlled-release preparations for biologically active materials and resulting compositions
TL;DR: In this article, a method and product for preparing a controlled-release composition are provided, which comprises formation of a mixture containing at least one amphiphilic substance capable of forming a liquid crystalline phase, in contact with a liquid selected from the group consisting of water, glycerol, ethylene glycol, propylene glyco and mixtures thereof.
Patent
Fat emulsion of prostaglandin i 2
TL;DR: A fat emulsion containing a prostaglandin is represented by the formula (I) wherein X represents an oxygen atom or a methine group, Y represents a carbon atom, and Z represents a methylene or methine groups as discussed by the authors.
Patent
Fatty emulsion of fine particle
TL;DR: In this article, the authors used a high pressure emulsifier to obtain a 10nm-40nm average particle diameter, which was then filled in ample and steam sterilized under pressure, thus made to a parenteral injection.
Patent
Carcinostatic-containing fatty emulsion
TL;DR: In this article, the authors proposed a method to obtain an inexpensive and safe carcinostatic-containing fatty emulsion by making a fat-soluble carcinostatics and an oily component with an emulsifying agent selected from phospholipid, lecithin, lysolecithins, etc.
Patent
Prostaglandin fat emulsion
TL;DR: In this article, a prescribed amount of an oil component (e.g. soybean oil) is mixed with a phospholipid free of phosphatidyl ethanolamine, prostaglandin (PG) and if necessary, an emulsifying assistant, a stabilizer, etc., the mixture is heated, and the resultant solution is homogenized with a homogenizer.
References
More filters
Patent
Pharmaceutical preparation for skin
TL;DR: In this paper, a pharmaceutical preparation for the skin having improved remedying activities, obtained by adding a phospholipid to an anti-inflammatory steroid, was presented, which is used as solution, gel, cream or ointment.