Open AccessJournal Article
The action of BC-105 in chronic schizophrenics with depression.
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This article is published in Current Therapeutic Research-clinical and Experimental.The article was published on 1968-07-01 and is currently open access. It has received 10 citations till now. The article focuses on the topics: Depression (differential diagnoses).read more
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Pizotifen(BC-105): A Review of its Pharmacological Properties and its Therapeutic Efficacy in Vascular Headaches
T. M. Speight,G. S. Avery +1 more
TL;DR: Pizotifen2 is a benzocycloheptathiophene derivative possessing a strong antagonistic action against certain biogenic amines, and has been shown to exert strong antiserotonin and antihistaminic effects, together with a weak anticholinergic activity.
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Pizotifen as an antidepressant.
TL;DR: Pizotifen seems to possess certain antidepressive effects in dosages of 4–10 mg daily, which could make it an alternative in treating patients suffering from the often seen combination of vascular headache/depression.
Journal ArticleDOI
The central action of pizotifen.
TL;DR: Results suggest that pizotifen strongly blocks the central postsynaptic serotonin receptors in mice, rats and rabbits, and is ineffective in classic tests for antidepressant activity.
Journal ArticleDOI
5-Hydroxytryptophan in the prophylaxis of migraine
TL;DR: The statistical evaluation shows significant differences between control and treatment periods, and no difference between methysergide and 5- HTP periods, which could support the serotonin theory of migraine, pointing out a possible brain 5-HT deficiency, and consequently central monoamine supersensitivity.