Journal ArticleDOI
The Effect of pH Adjustment of 0.5% Bupivacaine on the Latency of Epidural Anesthesia
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A randomized, double‐blind study to determine what effect raising the pH of 0.5% bupivacaine has on the latency of EA in patients undergoing lower extremity surgery finds no advantage.Abstract:
&NA; pH adjustment of lidocaine and 2‐chloroprocaine has been reported to decrease the latency of epidural anesthesia (EA). The effect of alkalinization of bupivacaine on onset of surgical anesthesia has not been adequately studied to date. To determine what effect raising the pH of 0.5% bupivacaine has on the latency of EA in patients undergoing lower extremity surgery, we performed a randomized, double‐blind study. Forty patients were randomly divided into two groups. Group I patients received 15 ml of a local anesthetic (LA) solution containing 0.5% bupivacaine and 0.15 mEq of NaHCO3. Group II patients received 15 ml of a standard solution of 0.5% bupivacaine. Both solutions contained freshly added epinephrine (1:200,000). After injection of LA via Tuohy needle, sensory testing was conducted using a safety pin. The pH of the LA used for Group I was 6.96 ± 0.01 and for Group II was 5.33 ± 0.11. No statistically significant difference was found between the anesthetic parameters tested in each group. On this basis, we find no advantage of pH adjustment of 0.5% bupivacaine for EA.read more
Citations
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Extradural, spinal or combined block for obstetric surgical anaesthesia
TL;DR: It is in obstetric anaesthesia, therefore, that the differences between extradural and spinal block may be most apparent, and in choosing between them it is necessary that the anaesthetist understands the relative merits of the two techniques.
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Onset of epidural blockade after plain or alkalinized 0.5% bupivacaine.
TL;DR: It is concluded that alkalinization of 0.5% bupivacaine offers no improvement in the onset of epidural blockade and no difference in motor blockade or upward spread of anesthesia was noted between the two groups.
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Alkalinization of local anaesthetics.
TL;DR: There is no local anaesthetic available that combines reliable quick onset (in 10 minutes or less for an epidural block) with a length of action of several hours with a number of studies reported comparisons between alkalinized and plain (unalkalinized) preparations of local anaesthetics.
Journal ArticleDOI
The procaine-(base)-infusion: A review after twenty years of use
Ralf Oettmeier,Uwe Reuter +1 more
TL;DR: It was shown that the classic Procaine-Base-infusion should be only realized on the base of a prior acid-base-diagnostic for the safety of the patients and to improve the success rate of the method.
References
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Journal ArticleDOI
Extradural, spinal or combined block for obstetric surgical anaesthesia
TL;DR: It is in obstetric anaesthesia, therefore, that the differences between extradural and spinal block may be most apparent, and in choosing between them it is necessary that the anaesthetist understands the relative merits of the two techniques.
Journal ArticleDOI
Onset of epidural blockade after plain or alkalinized 0.5% bupivacaine.
TL;DR: It is concluded that alkalinization of 0.5% bupivacaine offers no improvement in the onset of epidural blockade and no difference in motor blockade or upward spread of anesthesia was noted between the two groups.
Journal ArticleDOI
Alkalinization of local anaesthetics.
TL;DR: There is no local anaesthetic available that combines reliable quick onset (in 10 minutes or less for an epidural block) with a length of action of several hours with a number of studies reported comparisons between alkalinized and plain (unalkalinized) preparations of local anaesthetics.
Journal ArticleDOI
The procaine-(base)-infusion: A review after twenty years of use
Ralf Oettmeier,Uwe Reuter +1 more
TL;DR: It was shown that the classic Procaine-Base-infusion should be only realized on the base of a prior acid-base-diagnostic for the safety of the patients and to improve the success rate of the method.