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Open AccessJournal ArticleDOI

The Production of an Antifungal Antibiotic by Streptomyces griseus.

Alma J. Whiffen, +2 more
- 01 Nov 1946 - 
- Vol. 52, Iss: 5, pp 610-611
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TLDR
The phytochemical properties ofSaccharomyces cerevisiae, a type of baker's yeast, and its application in food spoilage and wound healing are revealed.
Abstract
Saccharomyces cerevisiae ATCC 918................ 2,500,000 <1,000 Cryptococcus neoforman ............... ............ 1,300,000 <1,000 Rhodotorula ep. ................................... 1,300,000 1,000 Hormodendrum pedrosoi 275........................ 20,000 <1,000 Monosporium apiospermum........................ 20,000 <1,000 Phialophora verrucosa............................. 20,000 <1,000 Blastomyces dermatitidis 930....................... <10,000 <1,000 Candidd albicans.................................. <10,000 ' <1,000 Coccidioides immitis 819........................... <10,000 <1,000 Epidermophyton floccosum......................... <10,000 <1,000 Geotrichum sp..................................... <10,000 <1,000 Hormodendrum compactum ......................... < 10,000 <1,000 Nocardia asteroides653.<10,000 <1,000 Sporotrichum schenkii ................ ............. < 10,000 <1,000 Trichophyton rubrum ............... ............... < 10,000 <1,000 Bacillus subtilis .................................... <10,000 28,000,000 Staphylococcus aureus FDA 209.................... <10,000 21,000,000 Escherichia coli .................................... <10,000 3,500,000 Pseudomonas aeruginosa ATCC 9027............... <10,000 350,000

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Journal ArticleDOI

Cycloheximide: aspects of inhibition of protein synthesis in mammalian cells.

H. L. Ennis, +1 more
- 11 Dec 1964 - 
TL;DR: Cyclo heximide and acetoxy-cycloheximide specifically inhibit protein synthesis in L-cells growing in suspension culture and in extracts of rat liver, the drugs inhibit transfer of amino acid from soluble RNA to polypeptide.
Journal ArticleDOI

The effect of actidione and other antifungal agents on nucleic acid and protein synthesis in Saccharomyces carlsbergensis.

D. Kerridge
- 01 Dec 1958 - 
TL;DR: The antifungal compound actidione has been found to inhibit both nucleic acid and protein synthesis in Saccharomyces carlsbergensis at the minimum growth inhibitory concentration.
Journal ArticleDOI

Site of action of cycloheximide in cells of Saccharomyces pastorianus. 3. Further studies on the mechanism of action and the mechanism of resistance in saccharomyces species.

TL;DR: Kinetics of cycloheximide-inhibited transfer of amino acids from soluble RNA to protein in a system from Saccharomyces pastorianus was further investigated and showed that resistance or susceptibility of the system to cyclo heximide is determined by the ribosomes and not by the supernatant enzymes.
Journal ArticleDOI

The Production, Assay, and Antibiotic Activity of Actidione, an Antiobiotic from Streptomyces griseus

TL;DR: It has been possible to determine the effect of changes in the composition of the fermentation medium upon the relative yields of actidione and streptomycin and to demonstrate that the amounts of the two antibiotics produced may vary independently of one another.
Journal ArticleDOI

Site of action of cycloheximide in cells of saccharomyces pastorianus. i. effect of the antibiotic on cellular metabolism.

TL;DR: It is concluded that the primary action of cycloheximide is the inhibition of protein synthesis and that alterations in cellular metabolism in treated cells is a reflection of disrupted protein synthesis.
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