Patent
Vitamin D3 derivatives having a substituent at 2-position
TLDR
A 1α-hydroxy vitamin D3 derivative of the formula is described in this article, where a process for preparing the same is described and the compound represented by the formula above has the calcium control action and the ability to induce differentiation in tumor cells and therefore are useful as an antitumor agents and a medicine for treating calcium dysbolism-caused diseases.Abstract:
A 1α-hydroxy vitamin D3 derivative of the formula: ##STR1## where R1 is a hydroxyl group, an amino group or the group: OR' (where R' is a lower alkyl group having 1 to 7 carbon atoms that may or may not be substituted by a hydroxyl group, a halogen atom, a cyano group, a lower alkoxy group having 1 to 3 carbon atoms, an amino group, or an acylamino group); R2 is a hydrogen atom or a hydroxyl group), and a process for preparing the same are disclosed. The compound represented by the formula above has the calcium control action and the ability to induce differentiation in tumor cells and, therefore, are useful as an antitumor agents and a medicine for treating calcium dysbolism-caused diseases.read more
Citations
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Journal ArticleDOI
New 1alpha,25-dihydroxy-19-norvitamin D3 compounds of high biological activity: synthesis and biological evaluation of 2-hydroxymethyl, 2-methyl, and 2-methylene analogues
TL;DR: It was established that vitamins possessing the axial orientation of the 1alpha-hydroxy substituent exhibit a significantly increased receptor binding affinity, and the present studies imply that the axia-Hydroxy group is necessary for biological activity of vitamin D compounds.
Patent
2-alkylidene-19-nor-vitamin d compounds
TL;DR: The 2-alkylidene-19-nor-vitamin D derivatives as mentioned in this paper have a formula (I) where Y1 and Y2, which may be the same or different, are each selected from the group consisting of hydrogen and a hydroxy-protecting group, R6 and R8, respectively, and when taken together represent the group -(CH2)x- where x is an integer from 2 to 5, and R represents any of the typical side chains known for vitamin D type compounds.
Patent
19-Nor-vitamin D3 compounds with substituent at 2-position
Hector F. DeLuca,Kato L. Perlman +1 more
TL;DR: In this paper, the 2α and 2β-hydroxy analogs of 19-nor-1α,25-dihydroxyvitamin D were evaluated in the treatment of osteoporosis.
Patent
2-alkyl-19-nor-vitamin D compounds
TL;DR: The 2-alkyl-19-nor-vitamin D derivatives as discussed by the authors have a formula (I) where Y1 and Y2, which may be the same or different, are each selected from the group consisting of hydrogen and a hydroxy-protecting group, R6 is selected from a group consisting alkyl, hydroxyalkyl and fluoroalkyl, and where the group R represents any of the typical side chains known for vitamin D type compounds.
Patent
1α-hydroxy-2-methylene-19-nor-homopregnacalciferol and its uses
TL;DR: In this article, a 1α-hydroxy-2-methylene-19-nor-homopregnacalciferol and pharmaceutical uses therefor were revealed.
References
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Patent
1 alpha,25-dihydroxy-2 beta-fluorovitamin d3
Alumni Res Found Wisconsin,Hector F. DeLuca,Heinrich K. Schnoes,Nobuo Ikekawa,Yoko Tanaka,Masuo Morisaki,Jun Ichi Oshida +6 more
TL;DR: New derivatives of vitamin D u, specifically, 1//c, 25-dihydroxy-2ss-fluorocholecalciferol, have been proposed as discussed by the authors.
Patent
1 alpha-hydroxy-2 beta-fluorocholecalciferol
TL;DR: New derivatives of vitamin D3, specifically, 1(Alpha)-hydroxy-2 (Alpha)-fluorocholecalciferol, have been developed as mentioned in this paper. But their performance is limited.