Are the effects of diabetic-derived ADSCs diminished?
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The effects of diabetic-derived ADSCs are diminished . High glucose conditions in diabetes lead to impaired biological functions of ADSCs, including decreased cell viability, migration, and proangiogenic capacity . Additionally, diabetes increases apoptosis of ADSCs, making wound healing difficult . However, there are potential strategies to restore the proangiogenic function of diabetic ADSCs. Overexpression of glyoxalase-1 (GLO1) in diabetic ADSCs reduces intracellular reactive oxygen species (ROS) accumulation, leading to improved cell viability, migration, and proangiogenic capacity . Another approach involves targeting the hsa_circ_0008500/hsa-miR-1273h-5p/ELK1 signaling cascade to attenuate ADSCs apoptosis and promote wound repair in diabetes . These findings suggest that the effects of diabetic-derived ADSCs can be restored through interventions that reduce ROS accumulation and regulate apoptosis-related signaling pathways.
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| Papers (4) | Insight |
|---|---|
| Yes, the effects of diabetic-derived ADSCs are diminished. The paper states that the therapeutic effects of diabetic ADSCs (D-ADSCs) are impaired by diabetes, possibly due to intracellular reactive oxygen species (ROS) accumulation. | |
14 Citations | The paper does not mention anything about "diabetic-derived" ADSCs. The paper is about the beneficial effects of PEDF-transfected ADSCs on erectile dysfunction in a streptozotocin-diabetic rat model. |
2 Citations | The paper does not directly mention whether the effects of diabetic-derived ADSCs are diminished. The paper primarily focuses on the general features and functions of diabetic ADSCs in relation to wound healing. |
| The paper does not mention anything about the effects of diabetic-derived ADSCs being diminished. |
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