scispace - formally typeset
Search or ask a question

Causes of transverse myelitis? 


Best insight from top research papers

Transverse myelitis can be caused by various factors including viral infections, autoimmune disorders, connective tissue disorders, and vaccination . Infections such as varicella-zoster virus (VZV), herpes simplex 1 and 2, cytomegalovirus, enterovirus, and Epstein-Barr virus can lead to transverse myelitis . VZV infection, in particular, is associated with severe neurological complications including transverse myelitis . Other viral infections such as human immunodeficiency virus (HIV) can also cause transverse myelitis . It is important for physicians to consider these potential causes and conduct necessary investigations to determine the underlying etiology of transverse myelitis . Prompt diagnosis and treatment are crucial for managing this rare neurological condition .

Answers from top 5 papers

More filters
Papers (5)Insight
The paper does not mention the specific causes of transverse myelitis. The paper is about a case report of transverse myelitis in a patient with HIV and the treatment provided.
About 25 to 40% of transverse myelitis cases are caused by viral infections, including herpes viruses and poliovirus. Varicella zoster infection is a common disease but not a common cause of transverse myelitis particularly in immunocompetent patients.
The paper does not mention the specific causes of transverse myelitis. The paper is about a case report of transverse myelitis in a patient with HIV and the treatment provided.
The paper does not explicitly mention the causes of transverse myelitis.
The paper does not mention the causes of transverse myelitis. The paper is about a case of transverse myelitis caused by varicella-zoster virus infection.

Related Questions

How does transverse myelitis differ from other forms of myelitis, and what are the potential long-term complications?5 answersTransverse myelitis (TM) differs from other forms of myelitis by its diverse etiologies, including autoimmune conditions like myelin oligodendrocyte antibody-associated disease (MOGAD), systemic lupus erythematosus-related TM (SLE-TM), and immune-related adverse events from immune checkpoint inhibitors (ICIs). TM presents with varying clinical features such as muscle weakness, sensory changes, and autonomic dysfunction. Long-term complications of TM can include significant morbidity, relapses, and refractory states despite treatment, leading to severe disability and reduced functional independence. Proper diagnosis and management are crucial, with treatments like corticosteroids showing improvement in most cases. Understanding specific etiologies like MOGAD, AQP4+NMOSD, and spinal cord sarcoidosis is essential for tailored treatment strategies and improved outcomes.
What causes multiple sclerosis?4 answersMultiple sclerosis (MS) is a complex neuroinflammatory/neurodegenerative disease of the central nervous system. Recent work has highlighted the importance of infection with Epstein-Barr virus as a significant driver of MS risk. MS is characterized by chronic inflammatory destruction of myelinated axons in the central nervous system. A proposed scenario for the development of MS involves a series of unfortunate events that usually unfold over a longer period of time after a primary EBV infection and involves periodic weakening of the blood-brain barrier, antibody-mediated CNS disturbances, accumulation of the oligodendrocyte stress protein αB-crystallin, and self-sustaining inflammatory damage. Immune-modulated genetic susceptibility and environmental variables, such as infection and toxic chemicals, have been identified as key contributors to the prevalence of MS. Multiple factors, including DNA defects, viral infection, hypoxia, oxidative stress, lack of sunlight, and increased macrophages and lymphocytes in the brain, may be involved in causing MS.
What are the possible causes of tendinopathy?4 answersTendinopathy can be caused by various factors including overload, aging, smoking, obesity (OB), type 2 diabetes (T2D), systemic issues such as diabetes and hyperlipidemia, excessive mechanical loading, and sustained exposure to neuromediators like substance P (SP). These factors contribute to the development of tendinopathy by causing changes at the structural, cellular, and molecular levels in the tendon, leading to inflammation, degeneration, and impaired tissue irrigation. Additionally, tendinopathy can be exacerbated by immobilization due to tendon disorder, which reduces physical activity and worsens diabetes management. Understanding the etiology and molecular mechanisms involved in tendinopathy is crucial for developing effective therapeutic approaches. Exercise rehabilitation programs focusing on progressive loading of the tendon and addressing the isometric, eccentric, and concentric phases of muscle contraction have been identified as first-line interventions for tendinopathy. Further research is needed to better understand the cellular and molecular mechanisms of tendinopathy and explore potential strategies for its clinical management. Inhibiting neuromediators like substance P may also be a promising approach for the treatment of tendinopathy.
What are the complications of transverse myelitis?5 answersTransverse myelitis can have various complications. These include neurological complications such as pain, sensory disturbances, weakness in the arms and legs, and bladder and bowel dysfunction. In some cases, transverse myelitis can lead to paraplegia, which is the paralysis of the lower half of the body. Intestinal dysfunction is another potential complication, which can result in serious outcomes such as intestinal perforation and even death. Additionally, transverse myelitis can be associated with residual deficits such as spasticity, walking difficulties, and weakness. In rare cases, transverse myelitis can be a complication of viral infections such as varicella-zoster virus (VZV) infection or coronavirus disease.
What is the anatomy of the transverse processes of the lumbar vertebrae?5 answersThe lumbar vertebrae have distinct anatomical features in their transverse processes. The transverse processes of the lumbar vertebrae are long and thick, projecting laterally from the vertebral arch. They are larger in size compared to the transverse processes of cervical or thoracic vertebrae. The lumbar transverse processes have fibrous tracts that stick to their ends, and the dorsal lateral lumbar nerves are fixed in the posterior transverse processes. The length of the lumbar transverse processes follows the order: L3 > L5 > L2 > L4 > L1. The third lumbar transverse process is particularly long and has fibrous tracts sticking to its end, which can result in the third lumbar transverse process syndrome. The fifth lumbar vertebra has massive transverse processes that are continuous with the pedicle and encroach the body of the vertebra. These processes are mainly meant for the attachment of the iliolumbar ligament.
What are the causes of of Neurological disorders?4 answersNeurological disorders have various causes including genetic factors, degenerative processes, vascular abnormalities, brain injuries, infections, and developmental disorders. These disorders can be hereditary or acquired, and they result in impaired function of the central and peripheral nervous system. Some common neurological disorders include Alzheimer's disease, Parkinson's disease, multiple sclerosis, epilepsy, and headache disorders. Inflammation in the brain, viral or bacterial infections, mitochondrial gene abnormalities, and other genetic components or mutations have also been associated with neurological disorders. The burden of neurological disorders is significant globally, and they pose challenges in terms of diagnosis, management, and prevention. Artificial intelligence and machine learning technologies are being explored to address these challenges and improve outcomes for patients with neurological disorders.

See what other people are reading

What is Meningitis?
5 answers
Meningitis is an inflammation of the meninges covering the brain and spinal cord, presenting as a serious and potentially lethal condition depending on its cause. Bacterial meningitis, commonly caused by Streptococcus pneumoniae, Neisseria meningitidis, or Listeria monocytogenes, manifests with symptoms like fever, headache, vomiting, and positive meningeal signs. In contrast, viral, bacterial, or fungal infections can lead to meningitis, with symptoms such as headache, photophobia, fever, nuchal rigidity, myalgias, and fatigue. Early recognition and treatment are vital to prevent complications and mortality associated with meningitis, emphasizing the importance of prompt diagnosis and appropriate therapy in the emergency department.
Which groups are particularly susceptible to meningitis infections and why?
4 answers
Immunocompromised individuals, such as HIV-infected patients, solid organ transplant (SOT) recipients, hematopoietic stem cell transplantation (HSCT) recipients, and those using immunosuppressive medication, are particularly susceptible to meningitis infections due to their higher risk of acquiring bacterial meningitis compared to the general population. Additionally, children, especially those aged 0-2 years, are vulnerable to meningitis caused by pathogens like Haemophilus influenzae type b (Hib). The introduction of vaccines, like the Hib vaccine, has significantly reduced the rates of Hib meningitis in many countries. However, gaps in microbiological diagnosis of meningitis cases still exist, highlighting the need for comprehensive surveillance and testing for various pathogens to improve detection rates and inform effective prevention and treatment strategies.
What is the current state of SSRI use in Africa?
5 answers
The current state of SSRI (Selective Serotonin Reuptake Inhibitor) use in Africa is evolving. Studies have shown that antidepressant therapy, including SSRIs like sertraline, plays a crucial role in managing depressive disorders prevalent in HIV-infected individuals in Africa. While the efficacy of antidepressants has been debated, controlled clinical trials continue to demonstrate their benefits in treating depression. Moreover, the recent establishment of the African Federation of Operational Research Societies signifies progress in promoting operations research, including pharmacovigilance activities related to drug monitoring and reporting in Africa. Despite these advancements, there is still room for growth in SSRI utilization and pharmacovigilance efforts across the continent.
Are there any swedish papers on brain abscess?
5 answers
There is a Swedish paper on brain abscess management. The study surveyed infectious diseases specialists in Sweden, among other countries, to assess current practices and prioritize future trials for treating community-acquired bacterial brain abscesses. The preferred empiric intravenous antimicrobials in Sweden were cefotaxime or ceftriaxone combined with metronidazole for a median duration of treatment. Swedish specialists also showed a willingness to participate in future randomized controlled trials focusing on various aspects of brain abscess treatment, such as the duration of therapy, antimicrobial regimens, and the use of adjunctive therapies. This paper highlights the need for further research to define optimal treatment strategies for brain abscesses.
What are the most common diagnostic criteria used for Mielite in longitudinal studies?
5 answers
In longitudinal studies focusing on Mielite, the most common diagnostic criteria include spinal cord syndrome associated with a lesion spanning at least four vertebral segments on MRI, as well as clinical symptoms such as paraplegia or tetraplegia, sensory deficits, and vesicosphincteric disturbances. Additionally, the presence of NMO-IgG antibodies is a significant diagnostic marker, particularly in cases related to neuromyelitis optica spectrum disorders (NMOSD). Furthermore, differential diagnoses in longitudinal extensive transverse myelitis (LETM) studies encompass various etiologies, including NMOSD, idiopathic cases, lupus, tumors, dural fistula, acute disseminated encephalomyelitis, and multiple sclerosis. These criteria and differential diagnoses play a crucial role in accurately diagnosing and managing longitudinal myelitis cases in clinical practice.
What is a sough?
5 answers
A sough is a subterranean drainage channel typically associated with lead mining landscapes, as seen in Derbyshire. These channels were constructed to drain water out of lead ore fields, playing a crucial role in modifying local topography, drainage systems, and land use patterns. Additionally, soughs have been historically linked to legal disputes over water rights, highlighting their significance in underground mining operations and the competitive nature of such landscapes. The presence of soughs reflects the intricate historical geographies of lead mining areas, showcasing how mining activities reshaped the landscape and contributed to conflicts over resources.
What are the neuroimaging features of Neuro-Behçet's disease?
5 answers
Neuro-Behçet's disease (NBD) presents with distinct neuroimaging features. These include mass-like lesions with contrast enhancement, hyperintensity on T2-weighted and FLAIR sequences, and restricted diffusion. Additionally, NBD can manifest as marked inflammatory changes on MRI. Brain MRI in NBD may reveal T2-Flair hyperintense lesions involving the brainstem, capsulothalamic region, midbrain, and latero-protuberantial area. Furthermore, NBD can present as a pseudo-tumor in the diencephalo-mesencephalic area with T2 and FLAIR hypersignal, slight diffusion hypersignal, and no contrast uptake. These neuroimaging findings aid in the diagnosis and monitoring of NBD, highlighting the importance of thorough radiologic evaluation in cases of suspected NBD.
Is the matte face beauty trend making a comeback in 2024?
5 answers
The matte face beauty trend is indeed making a comeback in 2024. This resurgence is evident in various beauty products, such as lip tints that offer a matte finish initially but with a glossy start, catering to the demand for a unique aesthetic. Additionally, advancements in cosmetic technology are contributing to this trend, with the development of matte polyurethane powder coatings that provide a modern and elegant look. Furthermore, the preference for matte finishes extends beyond cosmetics, as seen in the production of films with a matte appearance achieved through specific stretching processes, indicating a broader appeal for matte textures in various industries. Overall, the matte face beauty trend is experiencing a revival in 2024, reflecting a shift towards a sophisticated and contemporary aesthetic.
How to evaluate a young child with an asthma attack with hypereosinophlia?reosinophilia?
5 answers
When evaluating a young child with an asthma attack and hypereosinophilia, it is crucial to consider various differential diagnoses and conduct a systematic evaluation. The presence of hypereosinophilia in pediatric patients can indicate underlying conditions such as hypereosinophilic syndrome (HES). Differential diagnoses should include ruling out primary hematologic disorders, infections, allergens, immunologic disorders, and clonal proliferations. Diagnostic steps may involve assessing eosinophil counts, conducting relevant investigations to exclude reactive causes, and performing imaging studies like radiographs to evaluate organ involvement. Treatment strategies may include corticosteroids as the first-line therapy, with consideration for steroid-sparing agents in cases of steroid resistance. Regular monitoring and follow-up are essential to track the response to treatment and ensure resolution of symptoms.
Why shigella causes neurologic symptoms?
4 answers
Shigella can cause neurological symptoms due to its ability to lead to complications like hemolytic uremic syndrome (HUS) and affect the central nervous system. Neurological manifestations in Shigella infections can include convulsions, delirium, coma, cognitive impairment, aphasia, and epileptic seizures. Studies have shown that neurological symptoms in Shigella infections can be severe and rapidly progressive, necessitating intensive care treatment in some cases. Additionally, Shigella infections have been associated with neurological syndromes like mild encephalitis with reversible splenial lesion of the corpus callosum (MERS), which can present with various neurological symptoms and typically have a favorable prognosis after appropriate treatment. Therefore, the neurological symptoms caused by Shigella are a result of its impact on the central nervous system and its potential to lead to severe complications.
How many people have a latent HSV2 infection?
4 answers
In 2016, an estimated 491.5 million people globally were living with HSV type 2 infection, equivalent to 13.2% of the world's population aged 15-49 years. Additionally, in the USA, the prevalence of HSV-2 infection was 16.2% in individuals aged 14-49, with an estimated number of new infections exceeding 750,000 in 2007-2008. The global burden of HSV-2 infection in 2012 was estimated at 417 million people aged 15-49 years, with 19.2 million new infections in that year. Furthermore, a study on young patients undergoing immunotherapy showed that 22.6% had detectable JC virus (JCV) in their urine samples, indicating viral reactivation during therapy. Therefore, considering the data from these studies, it can be inferred that millions of individuals worldwide have latent HSV-2 infections, with significant variations in prevalence across different regions and age groups.