Do all monocytes/macrophages in mice express F4/80?
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Not all monocytes/macrophages in mice express F4/80. Research indicates that in the context of late-stage colorectal liver metastasis (CRLM), Ly6C+ CD11b+ F4/80- monocytes transform into Ly6C- CD11b int F4/80+ cells within the tumor microenvironment . Additionally, in Angiotensin II-induced hypertension (AHT), a subpopulation of renal macrophages (Mo) with a CD11c+F4/80+ phenotype was observed, suggesting a distinct phenotype from other monocytes/macrophages . Furthermore, myeloid-lineage cells in response to mechanical loading differentiate into CD68+ F4/80+ macrophages, which play a role in periosteal bone formation, indicating a specific subset expressing F4/80 . These findings collectively suggest that while some monocytes/macrophages express F4/80, not all monocytes/macrophages in mice exhibit this marker, highlighting the heterogeneity within these immune cell populations.
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| Papers (4) | Insight |
|---|---|
| Not all monocytes/macrophages in mice express F4/80. In the study, Ly6C+ CD11b+ F4/80- monocytes gained F4/80 expression before transforming into F4/80+ cells within the tumor microenvironment. | |
| Not all monocytes/macrophages in mice express F4/80. A specific subpopulation, renal Mo CD11c+-F4/80+, was identified, suggesting differential roles in hypertension and AT1R-dependent promotion. | |
| Not addressed in the paper. | |
14 Citations | Not addressed in the paper. |
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