Do open chromatin regions influence each other?
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Open chromatin regions do influence each other . The BAF complex is essential for maintaining open chromatin regions in epidermal differentiation . These BAF-dependent open chromatin regions are highly cell-type-specific and are enriched for binding sites for p63, a master epidermal transcription factor . BAF and p63 mutually recruit each other to maintain open chromatin regions . A Bayesian hierarchical approach using ATAC-seq data identified over 15,000 causal regulatory interactions in the human genome, highlighting the association genetics of chromatin state as a powerful approach for identifying interactions between regulatory elements . The Chromatin Interaction Neural Network (CHINN) can predict chromatin interactions between open chromatin regions using only DNA sequences . Open chromatin regions in the wild soybean genome are positively correlated with downstream gene expression and are associated with the activation histone mark H3K4me3 . The duplication of open chromatin regions may be essential for plant genome architecture and gene expression regulation .
Answers from top 5 papers
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| Papers (5) | Insight |
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| The paper does not directly address whether open chromatin regions influence each other. The paper focuses on identifying open chromatin regions in wild soybean and their effects on gene expression. | |
| The paper does not directly answer the question of whether open chromatin regions influence each other. The paper focuses on predicting chromatin interactions between open chromatin regions using DNA sequences. | |
76 Citations | The paper discusses a Bayesian hierarchical approach that identifies over 15,000 causal regulatory interactions between open chromatin regions in the human genome. Therefore, open chromatin regions do influence each other. |
| The paper does not directly address whether open chromatin regions influence each other. The paper focuses on the role of the BAF complex and p63 in controlling the open chromatin landscape during epidermal differentiation. | |
| The provided paper does not directly address the question of whether open chromatin regions influence each other. The paper focuses on the development of a comprehensive quality-checked database of open chromatin regions from sequencing data. |
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