Cancer related fatigue herbal medicine5 answersChinese herbal medicines have been evaluated for their effectiveness in treating cancer-related fatigue. Several studies have shown that Chinese herbal medicines can significantly improve fatigue scores in patients with gastric cancer, as well as improve quality of life and performance status. Additionally, Chinese herbal medicines have been found to be effective in treating cancer-related pressure ulcer wounds and constipation in patients with cancer-related symptoms. However, the effectiveness of Chinese herbal medicines in treating anorexia in cancer patients is inconclusive. It is important to note that more well-designed, multicenter, and large sample-sized randomized controlled trials are needed to further evaluate the effectiveness of Chinese herbal medicines on cancer-related fatigue and other symptoms.
Does Crizotinib affect fatigue and sleep in lung cancer patients?4 answersCrizotinib is an anticancer drug that has shown therapeutic efficacy in treating advanced nonsmall cell lung cancer (NSCLC) harboring ALK rearrangement. However, there is no specific mention of the effect of crizotinib on fatigue and sleep in lung cancer patients in the abstracts provided. One abstract discusses the high rate of symptom burden in lung cancer patients, including cancer-related fatigue (CRF), but does not mention the impact of crizotinib on fatigue and sleep. Another abstract focuses on the clinical characteristics of MET amplification in lung cancer and the response to crizotinib, but does not mention fatigue or sleep. Similarly, the other two abstracts discuss the efficacy of crizotinib in ALK-positive metastatic lung cancer and the use of immunohistochemistry (IHC) for determining ALK status, but do not mention fatigue or sleep. Therefore, based on the information provided, it is unclear whether crizotinib affects fatigue and sleep in lung cancer patients.
How long is there fatiguenesss after the oral intake of Capecitabine?3 answersFatigue after oral intake of Capecitabine was reported in several studies. In a study by Seltzer et al., no new or progressive toxicity was reported after the use of uridine triacetate as an antidote for capecitabine overdose or exposure. In another study by Harvey et al., fatigue was reported as a toxic effect of capecitabine, but the incidence was low, with grade ≥3 fatigue observed in 5% of patients. Similarly, in a study by Nolè et al., fatigue was reported as a frequently occurring adverse event, but it was rarely severe. Therefore, while fatigue can occur after the oral intake of Capecitabine, it is generally manageable and not severe.
Cancer Treatment and sleep cycle effects5 answersCancer treatment can have significant effects on the sleep cycle. Disruption of circadian rhythms and sleep cycles is associated with the development of cancer and can negatively impact the quality of life and survival of cancer patients. Chemotherapy delivery can be adapted to the molecular oscillations in drug pathways, resulting in safer and more effective treatments. Sleep disturbances are common among cancer patients, both before and during treatment, and can lead to persistent fatigue, altered mood, and poor adherence to cancer treatments. Sleep symptoms among cancer patients worsen over the course of chemotherapy but may improve in later cycles. Intervening before initiating chemotherapy or during the early cycles may be beneficial in reducing sleep disturbance among patients with lymphoma. Future studies are needed to gain a better understanding of the underlying mechanisms and causes of alterations in circadian rhythm in cancer patients.
What biomarkers correlate with fatigue in patients with lung cancer?5 answersFatigue in patients with lung cancer has been found to be correlated with several biomarkers. One study found that serum tartrate-resistant acid phosphatase 5a (TRACP5a) was positively correlated with symptom distress, including fatigue, in lung cancer patients undergoing chemotherapy. Another study found that increased plasma levels of tumor necrosis factor (TNF)-α and interleukin (IL)-1 were associated with cancer-related fatigue (CRF) in lung cancer patients. Additionally, an abnormally elevated level of 17-hydroxycorticosteroid (17-OHCS) in the urine was found to be a predictor of adverse reactions to chemotherapy, which can include fatigue. These findings suggest that TRACP5a, TNF-α, IL-1, and 17-OHCS may serve as biomarkers for fatigue in patients with lung cancer.
Can you use CPAP with lung cancer?5 answers