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Does allele frequency affect body odor?

Allele frequency

Olfactory system

Olfactory receptor

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Allele frequency does impact body odor. Individuals lacking body odor often possess a specific genotype related to the rs17822931 allele on ABCC11, resulting in "dry" earwax, common among East Asians . Studies on odor perception in different populations have revealed associations between specific olfactory receptors (ORs) and odors, indicating a genetic basis for odor perception . The presence of certain single-nucleotide polymorphisms (SNPs) in OR genes, such as OR51B2 and OR4D6, has been linked to the perception of underarm odor and musk compounds, respectively, shedding light on the genetic underpinnings of odor perception . These findings suggest that variations in allele frequencies of specific genes, like ORs, can indeed influence an individual's body odor perception.

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Open access•Journal Article•DOI From musk to body odor: Decoding olfaction through genetic variation Sijia Wang, B. K. Tyagi - Show less +1 more 03 Feb 2022-PLOS Genetics 5 Citations	Yes, allele frequency impacts body odor perception. Derived alleles associated with reduced odor sensitivity, suggesting primate olfactory gene repertoire degeneration over time.
Journal Article•DOI Allele frequency of CYP2C9 gene polymorphisms in Iran. Flora Peyvandi, Marta Spreafico, Mehran Karimi, Sirous Zeinali, P. M. Mannucci, A. Bianchi Bonomi - Show less +5 more 01 Nov 2002-Thrombosis and Haemostasis 20 Citations	Not addressed in the paper.
Open access•Journal Article•DOI Earwax and Armpits Mark V. Dahl 28 Aug 2013-NEJM Journal Watch	Yes, allele frequency of rs17822931 on ABCC11 affects body odor. Individuals with specific genotypes have dry earwax and lack body odor, with variations across ethnic groups.
Open access•Posted Content•DOI From musk to body odor: decoding olfaction through genetic variation Bufan Li, Bufan Li, Kamarck Ml, Kamarck Ml, Qianqian Peng, Lim F, Andreas Keller, Smeets Ma, Joel D. Mainland, Joel D. Mainland, Sumin Wang - Show less +10 more 28 Apr 2021-bioRxiv 1 Citations	Yes, allele frequency impacts body odor perception. Derived alleles of SNPs associated with odor tend to reduce intensity, suggesting primate olfactory gene repertoire degeneration over time.
Journal Article•DOI Allele frequency data for Profiler Plus Loci in Australia. Bruce S. Weir, Aleksander Bagdonavicius, Barry Blair, Carmen Eckhoff, Christopher Pearman, Peta Stringer, Julie Sutton, John West, Louise Wynen - Show less +8 more 01 Sep 2004-Journal of Forensic Sciences 10 Citations	Not addressed in the paper.

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