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Does E coli grow on complex substrates? 


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Yes, E. coli can grow on complex substrates. A study by Ziege et al. found that E. coli cells can build centimeter-large biofilms on nutritive hydrogels . Another study by Maser et al. investigated E. coli growth in a complex medium and found that amino acid depletions in the medium caused growth stops, which were overcome by modifying the medium based on amino acid utilization . Additionally, Peterson et al. studied E. coli growth on an agar substrate and found that metabolic cooperativity and colony behavior varied depending on strain-specific metabolic characteristics and the geometry of the substrate . Galvanauskas et al. developed control strategies for recombinant protein synthesis in E. coli cultivation processes, indicating that E. coli can efficiently utilize substrates for protein production . Finally, Poccia et al. developed a cybernetic model to represent the growth of E. coli strains on a medium containing glucose and glycerol, successfully simulating biomass growth and substrate consumption .

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The answer is not provided in the paper. The paper discusses the growth of E. coli on agar surfaces with varying geometric features, but it does not mention the growth of E. coli on complex substrates.
The answer is not in the paper. The paper is about the development and implementation of control strategies for recombinant protein synthesis in fed-batch E. coli cultivation process.
The paper states that E. coli can build centimeter-large biofilms on nutritive hydrogels, indicating that E. coli can grow on complex substrates.
The paper does not explicitly mention whether E. coli grows on complex substrates. The paper focuses on modeling the growth of E. coli strains on a medium containing glucose and glycerol as carbon and energy sources.
The paper does not directly answer the question of whether E. coli grows on complex substrates. The paper focuses on studying E. coli growth in a complex medium and modifying the medium for better growth performance.

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