Does PI3K–PKB pathway activity cause rhinitis?
Best insight from top research papers
The PI3K-PKB pathway activity has been implicated in the development of rhinitis. Studies have shown that inhibition of this pathway can lead to a reduction in eosinophilic inflammation and the Th2 immune response, resulting in the remission of allergic symptoms in mice with allergic rhinitis . Furthermore, the PI3K-PKB pathway was found to be suppressed by the treatment of alpha-Tocopherol (α-TCP), a form of vitamin E, in mast cells, suggesting that α-TCP can exert its anti-allergic function through the suppression of this pathway . These findings indicate that the activity of the PI3K-PKB pathway plays a role in the pathogenesis of rhinitis and targeting this pathway may have therapeutic potential for the treatment of rhinitis.
Answers from top 5 papers
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| Papers (5) | Insight |
|---|---|
| Yes, the activity of the PI3K-AKT pathway is implicated in the pathogenesis of allergic rhinitis. | |
| Yes, the activity of the PI3K-AKT pathway is implicated in the pathogenesis of allergic rhinitis. | |
| No, the PI3K-PKB pathway activity is suppressed in mast cells by α-Tocopherol, which has an anti-allergic function in allergic rhinitis. | |
| Yes, the PI3K-PKB pathway activity is implicated in the development of allergic rhinitis. | |
| The paper does not specifically mention rhinitis, but it suggests that the PI3K-Akt-HIF-1α pathway may reduce nasal airway inflammation and remodeling in nasal polyposis. |
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