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Does the compound "DL-ORNITHINE" have a positive or negative effect on human skin?

Ornithine decarboxylase

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DL-ORNITHINE has been studied for its potential effects on human skin. One study found that DL-ORNITHINE is an inhibitor of ornithine decarboxylase, a key enzyme in the polyamine biosynthetic pathway, and has shown promise in reducing the number of actinic keratoses (AKs), a type of skin lesion associated with skin cancer . Another study found that arginase activity and ornithine concentration were elevated in experimentally-induced benign tumors in mice, suggesting that determination of arginase activity could be useful for prognosis of skin tumors . However, it is important to note that the specific effects of DL-ORNITHINE on human skin are still being studied, and further research is needed to fully understand its potential positive or negative effects on human skin.

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Open access•Journal Article•DOI Targeting ornithine decarboxylase for the prevention of nonmelanoma skin cancer in humans. Craig A. Elmets, Mohammad Athar - Show less +1 more 01 Jan 2010-Cancer Prevention Research 38 Citations	The provided paper does not mention the specific compound "DL-ORNITHINE" and its effect on human skin.
Open access Arginase and Ornithine in Human Benign and Malignant Skin Tumors Cemal Kazezoğlu, Reyhan Yildiz, Beyhan Çakir, Mevlüt Türe - Show less +3 more 01 Jan 2010 2 Citations	The provided paper does not mention the effect of DL-ORNITHINE on human skin.
Journal Article•DOI Effects of L-Ornithine on Metabolic Processes of the Urea Cycle in Human Keratinocytes F. Höche, T. Klapperstück, Johannes Wohlrab - Show less +2 more 29 Oct 2004-Skin Pharmacology and Physiology 4 Citations	The provided paper does not mention the compound "DL-ORNITHINE" or its effects on human skin.
Open access•Journal Article Chemoprevention of human actinic keratoses by topical 2-(difluoromethyl)-dl-ornithine D.S. Alberts, Robert T. Dorr, Janine G. Einspahr, Mikel Aickin, Kathylynn Saboda, Min-Jian Xu, Y. M. Peng, Rayna Goldman, Janet A. Foote, James Warneke, Stuart J. Salasche, Denise J. Roe, George T. Bowden - Show less +12 more 01 Dec 2000-Cancer Epidemiology, Biomarkers & Prevention 91 Citations	The provided paper does not mention the compound "DL-ORNITHINE" and its effect on human skin.
Posted Content•DOI Data from Targeting Ornithine Decarboxylase for the Prevention of Nonmelanoma Skin Cancer in Humans 03 Apr 2023	The provided paper does not mention the specific compound "DL-ORNITHINE" and its effect on human skin.

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Does the compound "N,3-DIHYDROXYBENZAMIDE" have a positive or negative effect on human skin?5 answersN,3-Dihydroxybenzamide has a positive effect on human skin. It inhibits the activity of tyrosinase and melanin formation, which helps improve pigmentation in the skin. Additionally, it has been shown to have cytoprotective effects against oxidative stress and can protect cells from oxidative damage caused by H2O2 and UVB. The compound activates Nrf2 signaling cascades in keratinocytes, upregulates the antioxidant/cytoprotective enzyme heme oxygenase-1 (HO-1), and induces cytoprotective effects against oxidative stress. These findings suggest that N,3-dihydroxybenzamide has a positive effect on human skin by improving pigmentation and providing protection against oxidative damage.

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Does the compound "HIStadine HIStadine" have a positive or negative effect on human skin?5 answersThe compound "HIStadine HIStadine" has a positive effect on human skin. It has been shown to prevent the expression of late differentiation antigens in keratinocytes and decrease the expression of tight junction and desmosomal proteins, leading to the formation of a defective skin barrier. Additionally, histidine and histidinamide have been found to have cytoprotective effects in skin cells exposed to copper ions, mitigating oxidative stress and toxicity. These amino acids showed high copper chelation activity and suppressed copper-induced ROS production, glutathione oxidation, lipid peroxidation, and protein carbonylation in skin cells. Therefore, the compound "HIStadine HIStadine" can be beneficial for maintaining skin health and protecting against oxidative damage.

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How can I quantify ornithine in animal cell cultures?5 answersOrnithine can be quantified in animal cell cultures by using isoenzyme analysis. This method involves examining the G6PD and LDH patterns of the cells using starch gel electrophoresis. By analyzing the isoenzyme patterns, a "fingerprint" identification chart can be constructed for the ready identification of animal cells from different taxonomic groups. Although there are limitations to this technique, studying additional polymorphic enzymes can provide valuable information for the precise characterization of animal cells.

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