Does the role of helper lipid impact protein corona?
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The role of helper lipids does impact the protein corona formed on nanoparticles. Lipid composition influences the protein-liposome interaction, affecting membrane deformability, lipid intermixing, and the formation of lipid domains . Additionally, a single lipid switch can alter the nanoparticle protein corona profile, impacting cell transfection, biodistribution, and tumor-specific delivery efficiency . Furthermore, the presence of cholesterol in lipid nanoparticles affects the binding of bovine serum albumin (BSA) to the liposome surface, highlighting the importance of lipid composition in protein corona formation . These findings emphasize that the lipid composition of nanoparticles plays a crucial role in determining the nature and impact of the protein corona, ultimately influencing the nanoparticles' biological identity and interactions with cells.
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104 Citations | The paper does not specifically address the impact of helper lipids on the protein corona formation on polymeric nanoparticles exposed to mouse serum. |
| The study focuses on the impact of lipid and protein corona on iron oxide nanoparticles, showing how the adsorbed lipids and proteins influence colloidal stability, toxicity, and degradation behavior. | |
| Yes, the helper lipid composition impacts the protein corona formation on lipid nanoparticles, influencing in vivo targeted delivery and transfection efficiency in murine tumor models. | |
| Helper lipids do not directly impact protein corona in the context of spiky nanoparticles interacting with lipid bilayers, as the focus is on the influence of protein corona on nanoparticle behavior. | |
| The role of helper lipid impacts protein corona formation on lipid nanoparticles, influencing interactions with bovine serum albumin and suggesting implications for drug delivery design. |
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