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Dopamine affecting the blood brain barrier

Vascular endothelial growth factor B

Conditioned place preference

Nucleus accumbens

Mesolimbic pathway

Ventral tegmental area

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Dopamine can affect the blood-brain barrier (BBB) . Intravenous administration of dopamine can enhance dopamine levels in the nucleus accumbens and alter dopamine-related behaviors . Dopamine subtype-2 receptors (D2R) are involved in this enhancement of dopamine levels . Disruption of the BBB associated with endothelial dysfunction is observed in Parkinson's disease (PD) . 6-Hydroxydopamine (6-OHDA), a synthetic dopamine derivative used to model PD, increases the expression of endothelial adhesion molecules and induces endothelial inflammation . Nanoparticle-based technology loaded with dopamine can effectively cross the BBB and replenish dopamine in the nigrostriatal pathway, improving motor symptoms in a PD mouse model . Dopamine sulfate can permeate the BBB, but its fate in the brain is unclear . Dopamine-loaded PLGA nanoparticles can cross the BBB and deliver dopamine to the brain in a rat model of PD .

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Open access•Journal Article•DOI Permeation of Dopamine Sulfate through the Blood-Brain Barrier. Tina Suominen, T. Petteri Piepponen, Risto Kostiainen - Show less +2 more 24 Jul 2015-PLOS ONE 12 Citations	The paper does not directly address the effect of dopamine on the blood-brain barrier. The paper focuses on the permeation of dopamine sulfate through the blood-brain barrier.
Open access•Journal Article•DOI Dopamine-loaded nanoparticle systems circumvent the blood-brain barrier restoring motor function in mouse model for Parkinson's Disease. Victoria Monge-Fuentes, Andreia Biolchi Mayer, Marcos Robalinho Lima, Marcos Robalinho Lima, Luiza Ribeiro Geraldes, Larissa Nepomuceno Zanotto, Karla Graziella Moreira, Olímpia Paschoal Martins, Henrique Luís Piva, Maria Sueli Soares Felipe, Andre Correa Amaral, Anamélia Lorenzetti Bocca, Antonio Claudio Tedesco, Márcia Renata Mortari - Show less +13 more 26 Jul 2021-Scientific Reports 29 Citations	The paper does not directly address the effect of dopamine on the blood-brain barrier. The paper focuses on the design and testing of dopamine-loaded nanoparticle systems that can effectively cross the blood-brain barrier and restore motor function in a mouse model for Parkinson's Disease.
Open access•Journal Article•DOI 6-Hydroxydopamine induces brain vascular endothelial inflammation. Qizhi Fu, Runluo Song, Zhongxi Yang, Qi Shan, Wenna Chen - Show less +4 more 01 Nov 2017-Iubmb Life 12 Citations	The paper does not directly address the question of dopamine affecting the blood-brain barrier. The paper focuses on the effects of 6-hydroxydopamine (6-OHDA) on endothelial dysfunction and inflammation in the brain.
Open access•Journal Article•DOI Dopamine D2-Subtype Receptors Outside the Blood-Brain Barrier Mediate Enhancement of Mesolimbic Dopamine Release and Conditioned Place Preference by Intravenous Dopamine J Daniel Obray, Christina A. Small, Emily K. Baldwin, Eun Young Kang, Jin-gyeom Lee, Chae Ha Yang, Jordan T. Yorgason, Scott C. Steffensen - Show less +7 more 12 Jul 2022-Frontiers in Cellular Neuroscience 1 Citations	The paper does not directly address the effect of dopamine on the blood-brain barrier. The paper focuses on the involvement of dopamine subtype-2 receptors in enhancing dopamine release in the nucleus accumbens and related behaviors.

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