Dose topiramate for reassement epilepsy withdrawal symptoms on noncomplience patient
Best insight from top research papers
Topiramate has shown efficacy in managing refractory epilepsy. In patients with drug-resistant partial epilepsy, topiramate as an add-on treatment demonstrated a 50% or greater reduction in seizure frequency compared to placebo, with an overall odds ratio of 4.06 (95% CI: 2.86-5.78). However, withdrawal from treatment due to side effects was observed, with fatigue, weight loss, irritability, and other adverse events leading to discontinuation in some cases. Notably, topiramate doses above 400 mg per day did not show added advantage in efficacy, indicating that lower doses may be sufficient for many patients. Therefore, when reassessing epilepsy treatment in non-compliant patients, considering lower doses of topiramate may be beneficial to balance efficacy and tolerability.
Answers from top 5 papers
More filters
| Papers (5) | Insight |
|---|---|
72 Citations | Not addressed in the paper. |
27 Citations | Topiramate at 200mg daily is effective with fewer withdrawals due to adverse events, making it a suitable dose for managing partial epilepsy with good compliance. |
| Not addressed in the paper. | |
35 Citations | Topiramate withdrawal symptoms due to noncompliance in refractory epilepsy patients included ataxia, somnolence, metabolic acidosis, irritability, and psychotic symptoms, leading to treatment discontinuation in some cases. |
| Not addressed in the paper. |
Related Questions
Withdrawal symptoms of lamotrigine?4 answersWithdrawal symptoms of lamotrigine have been reported in several studies. These symptoms can include anxiety, emotional lability, irritability, and psychological distress, which occur in the hours before the next dose of medication is due. Abrupt discontinuation of lamotrigine has been found to worsen symptoms of rapid eye movement behavior disorder (RBD), with symptomatology becoming more severe and dreams becoming more vivid and frightening. In addition, lamotrigine withdrawal may also manifest as a psychomotor inhibition state, characterized by anhedonia, tremor, tachycardia, and hyperhidrosis, which resolves spontaneously after a few days. Furthermore, lamotrigine withdrawal may be associated with the development of mouth ulcers, which can be painful and resolve upon discontinuation of the medication. It is important for clinicians to be aware of these withdrawal symptoms and consider them when managing patients on lamotrigine therapy.
Can topiramate impact Thyroid?3 answersTopiramate is not mentioned in any of the provided abstracts.
What is the efficacy of Phentermine-topiramate for weight loss?5 answersPhentermine-topiramate therapy has been shown to be effective for weight loss in adults with overweight or obesity. Meta-analysis and systematic review of eligible trials found that phentermine-topiramate therapy resulted in an average weight loss of 7.73 kg compared to placebo. The weight loss was dose-dependent, with higher doses resulting in greater weight loss. Phentermine-topiramate therapy also reduced waist circumference, blood pressure, blood sugar levels, and lipid levels. However, it is important to note that phentermine-topiramate therapy increased the risk of nervous system-related adverse events, such as dysgeusia, paresthesia, dry mouth, and disturbance in attention. Further long-term clinical and pharmacological studies are needed to fully understand the efficacy and safety of phentermine-topiramate therapy.
Is ibuprofen better than topiramate for treating headache?3 answersIbuprofen and topiramate are both used for treating headaches, but it is unclear which one is better. Ibuprofen has been studied for the prevention of high altitude headache (HAH) and has shown efficacy in reducing the incidence of HAH compared to placebo. On the other hand, topiramate has been studied for the treatment of migraine headaches and has been found to be effective in reducing the frequency and severity of migraines. However, there is no direct comparison between ibuprofen and topiramate in the provided abstracts. Further research is needed to determine the comparative efficacy of these two medications for treating headaches.
What tablets do you take for epilepsy?4 answers
Which is not recommended drug for women with epilepsy?5 answers