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How can SHANK3 would be developed for cure ASD?

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SHANK3, a gene strongly associated with Autism Spectrum Disorder (ASD), holds promise for potential therapeutic development. Research indicates that SHANK3 mutations contribute to ASD symptoms, such as decreased excitability and spinal dysplasia. Studies using animal models with SHANK3 mutations have shown ASD-like behaviors, offering insights into neuropathological mechanisms and potential treatments. Gene therapy technologies like CRISPR present opportunities for targeted interventions in ASD, with SHANK3 and neuroligin being key targets for treatment. Additionally, medical cannabis enriched with CBD has shown promise in alleviating ASD symptoms in a SHANK3 mouse model, emphasizing the role of CB1 receptor signaling and neurotransmission-related gene expression. Understanding the role of SHANK3 in ASD pathogenesis and exploring treatments like gene therapy and CBD-enriched cannabis could pave the way for future therapeutic developments.

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Open access•Journal Article•DOI Shank3 influences mammalian sleep development Aude Cretin-Maitenaz 02 Sep 2022-Journal of Neuroscience Research 9 Citations	Not addressed in the paper.
Open access•Journal Article•DOI Behavioral aspects and neurobiological properties underlying medical cannabis treatment in Shank3 mouse model of autism spectrum disorder Shani Poleg, Emad Kourieh, Angela Ruban, Guy Shapira, Noam Shomron, Boaz Barak, Daniel Offen - Show less +6 more 13 Oct 2021-Translational Psychiatry 7 Citations	Not addressed in the paper.
Open access•Proceedings Article•DOI Practical use of CRISPR-Cas9 on SHANK3 and Neuroligin related to Autism Spectrum Disorder Zhen Li, Jiangnan Xiao, Haoning Xue - Show less +2 more 01 Jan 2022	CRISPR-Cas9 can be utilized to target SHANK3 and Neuroligin, key genes related to Autism Spectrum Disorder, offering a promising approach for potential therapeutic development.
Open access•Journal Article•DOI Social Deficits and Repetitive Behaviors Are Improved by Early Postnatal Low-Dose VPA Intervention in a Novel shank3-Deficient Zebrafish Model. Chun-xue Liu, Yi Wang, Jingxin Deng, Jia Lin, Chunchun Hu, Qiang Li, Xiu Xu - Show less +6 more 10 Sep 2021-Frontiers in Neuroscience 6 Citations	Low-dose VPA intervention postnatally in a shank3-deficient zebrafish model improves social deficits and repetitive behaviors, suggesting a potential therapeutic strategy for ASD.
Proceedings Article•DOI ASD-associated gene: SHANK3 Jiu-Ru Zhou 24 Mar 2023	Understanding SHANK3 mutations' role in ASD may lead to potential therapies. Research on SHANK3 gene modification and its association with ASD could pave the way for future treatment developments.

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