How can the stability of antibiotics be analyzed?
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The stability of antibiotics can be analyzed by conducting stability studies under various storage conditions . These studies involve measuring the concentrations of antibiotics in quality control samples at different time points and comparing them with the concentrations at the initial time point . Antibiotics are considered stable if the recovery results are between 85% and 115% . Short-term stability can be determined by assessing the stability of antibiotics at different temperatures and time durations, such as room temperature for 24 hours or refrigeration at 4-6°C for up to 72 hours . Long-term stability can be evaluated by storing plasma samples at -80°C for different durations, such as 6 months for some antibiotics and 12 months for others . Stability can also be affected by factors such as pH, buffer substances, light, and temperature . Analytical techniques such as ultraperformance convergence chromatography tandem mass spectrometry and liquid chromatography tandem mass spectrometry can be used to quantify the concentrations of antibiotics in stability studies .
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| The stability of antibiotics can be analyzed using High-Performance Liquid Chromatography (HPLC) as a separative analytical method, according to the provided paper. | |
| The stability of antibiotics can be analyzed by using high-performance liquid chromatography–diode array detection and ultraviolet spectrophotometry, as mentioned in the paper. | |
| The stability of antibiotics can be analyzed by studying the changes in concentration over time and determining the order and kinetic parameters of the reaction. The paper provides a methodology using thin-layer chromatography combined with densitometric analysis to analyze the stability of cefepime hydrochloride in various drug combinations. | |
| The stability of antibiotics can be analyzed by measuring the concentrations of the antibiotics in quality control samples at different time points and comparing them to freshly prepared calibration standards. | |
| The stability of antibiotics can be analyzed by measuring the concentrations of the antibiotics in quality control samples at different time points and comparing them to the concentrations at the initial time point (T = 0). |
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