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How do changes in neurotransmitter levels affect mood and behavior?

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Monoamine neurotransmitter

Nucleus accumbens

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Changes in neurotransmitter levels can significantly impact mood and behavior. For instance, imbalances in serotonin, dopamine, and norepinephrine levels have been linked to psychiatric disorders and mood swings, such as those observed in depression. Neurotransmitters like dopamine, serotonin, and noradrenaline play crucial roles in regulating social behaviors and emotional responses. Studies have shown that alterations in neurotransmitter levels, such as serotonin, dopamine, and glutamate, can lead to symptoms like anhedonia, a core feature of major depressive disorder. Moreover, disruptions in neurotransmitter levels due to factors like rapid eye movement sleep deprivation can result in mania-like behavior, highlighting the intricate relationship between neurotransmitters and behavioral outcomes. These findings underscore the critical influence of neurotransmitter levels on mood regulation and behavioral manifestations.

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Open access•Journal Article•DOI Neurotransmitter and Related Metabolic Profiling in the Nucleus Accumbens of Chronic Unpredictable Mild Stress-Induced Anhedonia-Like Rats Yan Li, Zhi Chen, Jianting Zhao, Heming Yu, Xiangyu Chen, Yong He, Yu Tian, Yue-Dan Wang, Chong Chen, Ke Chen, Peng Xie - Show less +10 more 29 Apr 2022-Frontiers in Behavioral Neuroscience	Changes in neurotransmitter levels, such as increased 5-HT and decreased Glu, impact mood and behavior, contributing to anhedonia-like behavior in depression, as shown in the study on CUMS-induced rats.
Journal Article•DOI Evaluation of Neurotransmitter Alterations in Four Distinct Brain Regions After Rapid Eye Movement Sleep Deprivation (REMSD) Induced Mania-Like Behaviour in Swiss Albino Mice. Saiful Alom Siddique, Thangavel Tamilselvan, Manikkannan Vishnupriya, Elumalai Balamurugan - Show less +3 more 18 Apr 2018-Neurochemical Research 15 Citations	Changes in neurotransmitter levels, such as dopamine, serotonin, norepinephrine, and GABA, can lead to mood and behavioral alterations, potentially contributing to mania-like behavior observed after REM sleep deprivation.
Book Chapter•DOI Neurotransmitter and Behaviour Manoj Kumar Bajaj 01 Jan 2020 2 Citations	Changes in neurotransmitter levels can profoundly affect behavior and mood. Alterations in neurotransmitter production can lead to significant behavioral and emotional consequences due to their role in regulating brain function.
Open access•Journal Article•DOI Monoamine neurotransmitters and mood swings: a dynamical systems approach. R. Loula, Luiz Humberto Figueiredo Monteiro - Show less +1 more 15 Feb 2022-Mathematical Biosciences and Engineering 2 Citations	Changes in serotonin, dopamine, and norepinephrine levels can lead to mood swings due to a potential transition from steady state to oscillatory behavior, impacting mood and behavior dynamics.

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