How do innate lymphoid cells contribute to the pathogenesis of rheumatoid arthritis?
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Innate lymphoid cells (ILCs) play a significant role in the pathogenesis of rheumatoid arthritis (RA) . ILCs are tissue-resident lymphoid cells that regulate the immune response through cytokine production . They are involved in the development of RA, with ILC1 being analogous to Th1, ILC2 to Th2, and ILC3 to Th17 cells . Alterations in the number and function of ILCs have been observed in RA patients . Specifically, the number of ILC2 cells is reduced in RA patients compared to healthy donors . The imbalance of ILCs may contribute to the development of RA . Further studies are needed to understand the subpopulation profile, phenotypic, and functional characteristics of ILCs in RA . The role of ILC2 in RA is presumed to be protective . Overall, ILCs represent a potential diagnostic biomarker and therapeutic target for RA .
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| Papers (4) | Insight |
|---|---|
| Innate lymphoid cells (ILCs) have been linked to the pathogenesis of rheumatoid arthritis (RA) through dysregulated activation and production of inflammatory cytokines in the joints. | |
| The paper mentions that innate lymphoid cells (ILC) play a role in the pathogenesis of rheumatoid arthritis (RA) by being present in the synovial membrane and synovial fluid, along with other immune cells. However, it does not provide specific details on how ILC contribute to the pathogenesis of RA. | |
| ILCs may play a role in the development of rheumatoid arthritis, as they are "innate analogues" of T helper cells and produce similar cytokines. However, the specific contribution of ILCs to the pathogenesis of RA is not mentioned in the paper. | |
| The paper states that innate lymphoid cells (ILCs) contribute to the pathogenesis of rheumatoid arthritis (RA), but does not provide specific details on how they do so. |
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