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How does chronic stress affect cyp11a1 expression?

Downregulation and upregulation

Response element

Glucocorticoid secretion

Steroid biosynthesis

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Chronic stress can impact CYP11A1 expression differently based on the specific stress model. In the context of the chronic mild stress (CMS) model of depression, it was observed that CMS moderately affects CYP expression, including CYP2B, CYP2C11, and CYP3A, with varying effects compared to other stress types. On the other hand, exposure to psycho-emotional stress (PES) led to a significant decrease in CYP2E1 expression in the liver of mice, attributed to intensified peroxide processes and oxidative stress. These findings highlight the complex relationship between chronic stress and CYP expression, indicating that different stressors can lead to distinct alterations in cytochrome P450 enzyme levels, potentially influencing steroid metabolism and physiological functions.

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Open access•Journal Article•DOI Mutation of Mouse Cyp11a1 Promoter Caused Tissue-Specific Reduction of Gene Expression and Blunted Stress Response without Affecting Reproduction Meng Chun Shih, Nai Chi Hsu, Nai Chi Hsu, Chen-Che Jeff Huang, Tzong Shoon Wu, Pao Yen Lai, Pao Yen Lai, Bon Chu Chung - Show less +7 more 03 Jan 2008-Molecular Endocrinology 28 Citations	Chronic stress reduces Cyp11a1 expression, leading to decreased glucocorticoid secretion and impaired stress response, as shown in the study on mouse Cyp11a1 promoter mutation.
Open access•Journal Article•DOI Targeted Protection of Mitochondria of Mesophyll Cells in Transgenic CYP11A1 CDNA Expressing Tobacco Plant Leaves After NaCl-Induced Stress Damage E. N. Baranova, Marat R. Khaliluev, Svetlana G. Spivak, Svetlana G. Spivak, Lilia R. Bogoutdinova, V.N. Klykov, O. G. Babak, Dmitry G. Shpakovski, A. V. Kilchevsky, Elena K. Shematorova, George V. Shpakovski - Show less +10 more 01 Dec 2018 4 Citations	Not addressed in the paper.
Open access•Journal Article•DOI CYP11A1 Upregulation Leads to Trophoblast Oxidative Stress and Fetal Neurodevelopmental Toxicity That can be Rescued by Vitamin D. Xiang Wang, Mengxue Li, Xueguang Zhang, Yaqian Li, Guolin He, Andras Dinnyes, Qun Sun, Wenming Xu - Show less +7 more 15 Feb 2021-Frontiers in Molecular Biosciences 2 Citations	Not addressed in the paper.
Open access•Journal Article•DOI The Effect of Chronic Treatment with Lurasidone on Rat Liver Cytochrome P450 Expression and Activity in the Chronic Mild Stress Model of Depression Marta Kot, Anna Haduch, Mariusz Papp, Władysława A. Daniel - Show less +3 more 01 Jan 2017-Drug Metabolism and Disposition 12 Citations	Chronic stress moderately affects CYP2C11 expression in the liver, as observed in the chronic mild stress model of depression in rats.

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