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How does hepatoma-derived growth factor (HDGF) regulate EMT? 

Neurogenesis
Neural stem cell
Oligodendrocyte
Subventricular zone
Hepatoma-derived growth factor
Best insight from top research papers

Hepatoma-derived growth factor (HDGF) plays a significant role in regulating EMT through various mechanisms. In prostate cancer, HDGF knockdown inhibits EMT by upregulating E-cadherin and downregulating N-cadherin, Vimentin, Snail, and Slug proteins . Additionally, HDGF promotes EMT in hepatocellular carcinoma by upregulating HGF and c-Met expression, leading to increased migration of tumor cells . Furthermore, in gastric cancer, HDGF enhances tumor cell survival and invasive motility by recruiting mesenchymal stem cells and promoting their differentiation into myofibroblast-like cells . These findings collectively demonstrate that HDGF influences EMT by modulating key proteins and pathways involved in cellular migration, invasion, and metastasis in various types of cancer.

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Papers (5)Insight
Open access•Journal Article•DOI
Hepatoma-derived growth factor functions as an unfavorable prognostic marker of human gliomas.
Yang Yang, Shengru Liang, Yuqian Li, Fei Gao, Longlong Zheng, Shilai Tian, Pu Yang, Lihong Li 
01 Dec 2017-Oncology Letters
6 Citations
Not addressed in the paper.
Open access•Journal Article•DOI
Helicobacter pylori Infection-Induced Hepatoma-Derived Growth Factor Regulates the Differentiation of Human Mesenchymal Stem Cells to Myofibroblast-Like Cells
Chung-Jung Liu, Yao-Kuang Wang, Fu-Chen Kuo, Wen-Hung Hsu, Fang-Jung Yu, Shuchen Hsieh, Ming-Hong Tai, Ming-Hong Tai, Deng-Chyang Wu, Chao-Hung Kuo 
30 Nov 2018-Cancers
19 Citations
Hepatoma-derived growth factor (HDGF) promotes differentiation of human mesenchymal stem cells to myofibroblast-like cells, contributing to EMT in gastric cancer progression.
Proceedings Article•DOI
Activated Monocyte-derived TNF-α Upregulates HGF/c-Met to Trigger EMT of Hepatoma Cells
Xinye Zhang
22 May 2020
Activated monocyte-derived TNF-α upregulates HGF/c-Met, triggering EMT in hepatoma cells by increasing HGF and c-Met expression, promoting EMT markers, and enhancing cell migration via HGF-c-Met signaling.
Open access•Journal Article•DOI
Hepatoma Derived Growth Factor Enhances Oligodendrocyte Genesis from Subventricular Zone Precursor Cells
Yutong Li, Nicole L Dittmann, Adrianne E.S. Watson, Monique Marylin Alves de Almeida, Tim Footz, Anastassia Voronova 
01 Jan 2022-Asn Neuro
3 Citations
Not addressed in the paper.
Open access•Journal Article•DOI
Downregulated expression of hepatoma-derived growth factor inhibits migration and invasion of prostate cancer cells by suppressing epithelial-mesenchymal transition and MMP2, MMP9.
Feilong Yang, Nengwang Yu, Hui Wang, Cong Zhang, Zhao Zhang, Yanxiang Li, Dawei Li, Lei Yan, Hainan Liu, Zhonghua Xu 
04 Jan 2018-PLOS ONE
26 Citations
HDGF regulates EMT by downregulating mesenchymal markers (N-cadherin, Vimentin, Snail, Slug) and upregulating the epithelial marker E-cadherin, inhibiting migration and invasion in prostate cancer cells.

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