How does levodopa interact with proteins?
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Levodopa interacts with proteins through various mechanisms. It has been observed that protein limitation and redistribution diets can improve motor fluctuations in Parkinson's disease patients on levodopa . Levodopa can bind to human serum albumin (HSA) and cause fluorescence emission quenching, altering the secondary structure of the protein . Additionally, levodopa can be incorporated into proteins in vivo, leading to increased levels of protein-incorporated dopa in lymphocyte cell proteins . This incorporation is not due to oxidative pathways and could potentially occur in the central nervous system as well . The interaction between levodopa and protein intake can be resolved by decreasing protein intake and changing the nutritional administration method . Overall, these findings suggest that levodopa can interact with proteins, affecting its pharmacokinetics and potentially contributing to motor fluctuations and neurotoxic effects in Parkinson's disease patients .
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39 Citations | The paper provides evidence that levodopa can be incorporated into proteins in vivo, potentially leading to the accumulation of toxic proteins and contributing to the adverse effects of long-term levodopa treatment. |
47 Citations | The paper states that levodopa (L-dopa) interacts with human serum albumin (HSA) through hydrogen bonds and hydrophilic forces, specifically binding to the subdomain IIIA of HSA. |
30 Citations | The paper mentions that levodopa interacts with proteins in enteral nutrition by competing with levodopa absorption, resulting in decreased efficacy. |
26 May 2016 | The paper mentions that large neutral amino acids (LNAA), which are components of proteins, can compete with levodopa for absorption into the brain. However, the data on the role of plasma LNAA concentrations in motor fluctuations is variable. |
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