How does rifaximin influence cognitive function?
Best insight from top research papers
Rifaximin, a non-absorbable antibiotic, exerts beneficial effects on cognitive function through various mechanisms. Studies show that rifaximin reduces neuroinflammation in the hippocampus, normalizes glutamate receptor expression, and improves spatial memory. Additionally, rifaximin protects against cognitive impairment induced by circadian rhythm disruption by modulating gut microbiota, enhancing intestinal barrier integrity, and suppressing inflammatory responses. Furthermore, rifaximin has been found to influence functional brain connectivity, particularly in the insular cortex, affecting cognitive flexibility and memory processing. Moreover, rifaximin's neuroprotective effects involve enhancing autophagy, inhibiting amyloid-β accumulation, and promoting neuronal protection in the hippocampus. Overall, rifaximin's multifaceted actions on neuroinflammation, gut microbiota, brain connectivity, and autophagy contribute to its positive impact on cognitive function in various conditions.
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| Papers (5) | Insight |
|---|---|
| Rifaximin improves cognitive function by ameliorating hyperammonemia and cognitive dysfunction in cirrhotic patients, as shown in the study. | |
| Rifampicin improves cognitive function by reducing amyloid-β accumulation through enhancing autophagy and inhibiting the Akt/mTOR/p70S6K signaling pathway in the hippocampus of LPS-induced mice. | |
3 Citations | Rifaximin modulates cognitive function by altering cortical functional connectivity, particularly in the insular cortex, impacting cognitive flexibility and memory processing through frequency-specific changes in brain activity. |
| Rifaximin protects cognitive function by preserving gut barrier integrity, reducing inflammation, reversing neurogenesis impairment, tau hyperphosphorylation, and synaptic protein loss induced by circadian rhythm disruption in mice. | |
| Rifaximin reduces neuroinflammation, normalizes glutamate receptor expression, and improves spatial memory in rats with liver damage, enhancing cognitive function by reversing these impairments. |
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