How does the accumulation of ROS affect the quality and viability of bovine oocytes?
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The accumulation of reactive oxygen species (ROS) has a significant impact on the quality and viability of bovine oocytes. Increased ROS levels during oocyte in vitro maturation (IVM) can have deleterious effects on the cells, leading to lower rates of nuclear and cytoplasmic maturation . Additionally, high levels of ROS are associated with oxidative stress, which can result in damage to cell structures and alteration of macromolecules, such as lipids, proteins, and nucleic acids . On the other hand, oocytes have mechanisms to evade ROS by remodeling the mitochondrial electron transport chain (ETC) through elimination of complex I. Early oocytes exhibit reduced levels of complex I and activate the mitochondrial unfolded protein response to maintain cellular fitness . These findings suggest that maintaining a balance between essential mitochondrial activity and ROS production is crucial for the quality and viability of bovine oocytes.
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| Papers (4) | Insight |
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| The provided paper does not specifically mention the effect of ROS accumulation on the quality and viability of bovine oocytes. | |
| The paper does not directly mention the accumulation of ROS and its effect on the quality and viability of bovine oocytes. The paper focuses on investigating various factors related to oocyte quality and embryo development in a model of low ovarian reserve. | |
| The provided paper does not mention bovine oocytes. It focuses on human and Xenopus oocytes. Therefore, there is no information in the paper about how the accumulation of ROS affects the quality and viability of bovine oocytes. | |
| The paper states that an increase or decrease in ROS levels beyond a physiological level significantly reduces nuclear or cytoplasmic maturation rates in bovine oocytes. However, it does not specifically mention the effect on quality and viability. |
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