Search or ask a question

How does the inclusion of zinc affect the potency and mechanism of action of botulinum toxin?

Randomized controlled trial

Cochrane Library

Clostridium botulinum

Best insight from top research papers

The inclusion of zinc in botulinum toxin compositions has shown promising effects on potency and duration. Studies have indicated that zinc supplementation can enhance the action and longevity of botulinum toxin in facial muscles, leading to significant improvements in conditions like hemifacial spasms, blepharospasms, and cosmetic facial rhytids . Zinc plays a crucial role in zinc-dependent reactions, potentially optimizing the effects of botulinum toxin by ensuring the ideal scenario for chemical muscle denervation . Additionally, the combination of zinc with botulinum toxin has been found to increase the survival rate of rats and prolong toxin efficacy duration when administered intramuscularly, highlighting its impact on safety and efficacy . Further research and larger clinical trials are recommended to fully elucidate the role of zinc in maximizing the effects of botulinum toxin .

Answers from top 4 papers

PDF

Open Access

More filters

Papers (4)	Insight
Open access•Journal Article•DOI The optimization of the results of chemical muscle denervation through the reconstitution of botulinum toxin type a in a sterile injectable physiological vehicle enriched with zinc Marco Antonio Matrone, Marcia Maria Gomes da Costa, Marília Capelli Barca, Taynan Rodrigues Matrone, Kiroit Ikeoka, Suellen Carneiro Silva, Darlene Cruz Vieira, Alessandra Nogueira Porto - Show less +7 more 02 Mar 2022-Health and Society	The inclusion of zinc in the reconstitution of botulinum toxin type A can optimize its potency by supporting zinc-dependent reactions, enhancing the mechanism of action for chemical muscle denervation.
Journal Article•DOI Botulinum Toxins and Zinc: From Theory to Practice—A Systematic Review Marcos Dantas dos Santos 20 Jun 2023-Clinical Neuropharmacology	Zinc supplementation enhances botulinum toxin's effect and longevity, improving outcomes in neurological conditions and cosmetic uses. It potentially maximizes the toxin's potency through synergistic action.
Journal Article•DOI Botulinum Toxins and Zinc: From Theory to Practice—A Systematic Review Jerome Kaikati, Elio Kechichian - Show less +1 more 20 Jun 2023-Clinical Neuropharmacology	Zinc supplementation enhances botulinum toxin's effect and longevity, potentially improving potency in neurological conditions and cosmetic uses, as indicated by the systematic review.
Open access•Journal Article•DOI Effects of zinc supplementation on duration and action of botulinum toxin applied to face muscles: A systematic review of randomized clinical trials Caroline dos Santos Melo, Ramara Kadija Fonseca Santos - Show less +1 more 01 Sep 2023-Journal of trace elements and minerals	Zinc supplementation, particularly zinc citrate with phytase, can enhance the duration of botulinum toxin treatment on facial muscles, potentially improving outcomes, but evidence supporting this practice is limited.

My columns

Related Questions

What is the mechanism by which zinc inhibits the replication of viruses in mucous membranes?5 answersZinc inhibits viral replication in mucous membranes through various mechanisms. In the context of COVID-19, zinc acts as an anti-viral agent by inhibiting virus entry and membrane fusion, particularly by interacting with the spike protein of SARS-CoV-2. Additionally, zinc has been shown to disrupt the viral life cycle of herpes simplex virus by inactivating viral enzymes essential for attachment and replication. Furthermore, zinc supplementation has demonstrated antiviral effects against rotavirus and dengue virus infections by inducing host antiviral responses, modulating zinc homeostasis, and activating interferon signaling pathways, ultimately inhibiting viral replication in epithelial cells. These findings highlight zinc's diverse antiviral mechanisms in combating viral infections in mucous membranes.

What is the effect of zinc on fibrosis?5 answersZinc supplementation has been shown to have beneficial effects on fibrosis in various organs. In the liver, zinc supplementation suppresses liver fibrosis and inflammation by inhibiting hepatic stellate cell activation and M1 macrophage polarization. In the lung, zinc deficiency aggravates oxidative stress and inflammation, leading to fibrosis. In patients with autoimmune hepatitis, long-term zinc supplementation improves serum fibrosis indices through increases in matrix metalloproteinases (MMPs) and is expected to be combined with antifibrotic therapies. In the kidney, zinc deficiency increases inflammation and collagen expression, exacerbating fibrosis. Overall, zinc plays a protective role in fibrosis by reducing inflammation, oxidative stress, and collagen deposition, and by modulating the expression of MMPs and tissue inhibitors of metalloproteinases (TIMPs).

Does Zinc have an impact on testosterone levels in human males?5 answersZinc has been found to have an impact on testosterone levels in human males. Studies have shown that seminal zinc concentration is positively related to testosterone levels, while serum zinc concentration is negatively related to testosterone levels. Additionally, a study on smokers found that cigarette smoking decreased zinc and testosterone hormone levels significantly, and zinc treatment failed to compensate for the decrease in testosterone levels. However, another study found that zinc supplementation had no significant effects on testosterone levels in response to exercise in subjects with a balanced diet, although free testosterone levels were increased by exercise after zinc supplementation. Overall, the relationship between zinc and testosterone levels in human males appears to be complex and may be influenced by various factors such as smoking and exercise.

Why is zinc necessary for children?5 answersZinc is necessary for children because it plays various roles in different biological processes, including cellular growth, cellular differentiation, and metabolism. Zinc deficiency can lead to impaired growth and development in children and increased susceptibility to infections. Zinc supplements have been shown to be effective in the treatment and prevention of upper respiratory tract and intestinal infections in children. Zinc also modulates the body's defense against infections, and severe forms of infectious diseases can lead to low plasma zinc concentrations in children. Serum zinc levels should be measured in children's follow-ups to ensure normal growth and development and protection from diseases. Zinc is essential for the maturation and functions of immune cells, and its deficiency can impair immune functions and increase susceptibility to infections in children. However, low serum zinc levels do not increase the risk of febrile urinary tract infection in children.

Can zinc and vitamin B complex be taken together?7 answers

Which nasal spray has zinc in it?5 answers

See what other people are reading

What has been studied in scientific articles about scuba diving and mindfulness?

Scientific articles have explored the benefits of scuba diving in relation to mindfulness. Studies have shown that scuba diving, with its similarities to meditation and mindfulness techniques, can reduce perceived stress and improve well-being. Additionally, research has highlighted the positive effects of meditative scuba diving on symptoms of Post-Traumatic Stress Disorder (PTSD), such as intrusion symptoms, although long-term mindfulness practice is necessary for stable benefits. Furthermore, investigations have delved into the psychophysiological and cognitive responses induced by military training related to submarine escape, showing that mindfulness levels influence stress reactions and cognitive degradation in submariners. Overall, these studies underscore the potential of scuba diving as a therapeutic tool for enhancing mindfulness and reducing stress.Can procrastination affect the training engagement of an athlete?

Procrastination can indeed impact the training engagement of athletes. Research has shown that procrastination levels among student athletes can vary, with some showing moderate tendencies. Studies have also explored how different factors, such as goal focus, can influence procrastination and successful goal pursuit in training programs. Additionally, interventions like the ON.TOP program with SMS support have been effective in reducing procrastination and increasing training behavior among students. Furthermore, dedicating more time to physical activity has been linked to lower levels of procrastination and a more positive perception of quality of life among practitioners, indicating a potential solution to counteract procrastination in athletes. Therefore, addressing procrastination through targeted interventions and time management strategies can enhance athletes' training engagement and overall performance.What are the current researches on measles and rubella vaccine microneedle patch ?

Current research on measles and rubella vaccine microneedle patches focuses on enhancing vaccine coverage and stability. Studies demonstrate that microneedle patches offer advantages like simplified administration, increased thermostability, and reduced wastage, potentially increasing vaccination coverage. Excipient screening has identified optimal formulations for maintaining vaccine potency during drying and storage, with pH buffering playing a crucial role. Additionally, innovative needle-free delivery devices like microarray patches are being explored to overcome implementation barriers and improve vaccine delivery in low- and middle-income countries, contributing to global immunization goals. Research also highlights the potential of microneedles to induce a robust immune response, offer pain-free administration, and enable the delivery of particle-based vaccines, showing promise for future vaccine delivery methods.Hat qualitative analyse von Natriumdodecylsulfat Interferenzen mit Spironolacton?

The qualitative analysis of Sodium Dodecyl Sulfate (SDS) does not directly interfere with Spironolactone. Spironolactone, a mineralocorticoid receptor antagonist, was studied in the SPIREN trial involving renal transplant patients. The trial aimed to assess the impact of Spironolactone on renal injury, fibrosis, and function. Results showed that Spironolactone did not improve long-term renal function or proteinuria in transplant patients. While there was a reduction in chrome-EDTA clearance in the Spironolactone group, it was attributed to a reversible hemodynamic effect rather than interference with SDS. Further analysis is needed to determine if Spironolactone can mitigate interstitial fibrosis progression in renal transplant patients.WHAT IS CONSIDERED REMISION IN psoriatic arthritis?

Remission in psoriatic arthritis (PsA) is defined as the absence of disease activity, encompassing various aspects such as the absence of signs and symptoms, physical well-being, lack of disease impact, absence of inflammation in imaging tests, and normal inflammatory biomarkers like ESR and CRP. Achieving remission or at least low disease activity is a realistic goal in PsA, with treat-to-target strategies like using disease activity scores such as DAPSA and MDA, especially in patients at high risk of structural damage progression. While the definition of remission in PsA remains controversial, it is clear that it should not solely focus on joint involvement but encompass all major disease manifestations for a comprehensive assessment.What is the effect of homecooking on budgeting money making family recipes?

Home cooking has a significant impact on family health and nutrition. Research shows that interventions focusing on home-based food parenting and nutrition lead to positive outcomes, such as improved diet quality. Additionally, studies highlight that the frequency of home cooking is associated with cardiovascular health in adolescents, with higher home cooking frequency linked to better health outcomes. Furthermore, innovative intervention methods, including ecological momentary intervention, video feedback, and home visiting by Community Health Workers, aim to enhance the quantity and quality of family meals to improve child cardiovascular health. Therefore, promoting home cooking through budget-friendly family recipes can positively influence both health and financial aspects within families.What are the potential side effects or risks associated with using bitter melon for weight loss purposes?

Bitter melon, known for its medicinal properties, has been traditionally used for various health benefits, including weight loss. Studies have highlighted the diverse pharmacological functions of bitter melon, such as antidiabetic, anti-inflammatory, and anti-obesity effects. Research on bitter melon extract's safety profile indicates its non-toxic nature, with no observed adverse effects even at high doses in animal studies. However, caution is advised when using bitter melon for weight loss due to its potential laxative properties, which could lead to gastrointestinal discomfort or diarrhea, especially when consumed in large amounts. Additionally, bitter melon's impact on glucose metabolism and insulin levels should be monitored, as it may affect individuals with prediabetes or diabetes. Regular monitoring and moderation in consumption are recommended to mitigate any potential risks associated with using bitter melon for weight loss purposes.Whats the effect of shared decission making in physiotherapy

Shared decision making (SDM) in physiotherapy has a significant impact on improving evidence-based practice, patient-clinician communication, and patient involvement in decision-making processes. SDM involves patients and clinicians collaboratively making health-related decisions based on available options, benefits, harms, patient values, preferences, and circumstances. Studies show that SDM education using clinical practice guidelines enhances self-efficacy in physiotherapists and occupational therapists, leading to improved attitudes, beliefs, and interest in evidence-based practice. Patients' involvement in SDM is associated with personal characteristics like age and educational status, with older and less educated patients showing a tendency towards non-involvement. Successful SDM in musculoskeletal physiotherapy requires trust, effective communication, shared power, and consideration of decision preferences and abilities. Integrating SDM into physiotherapy practice not only benefits patients but also enhances interprofessional collaboration for optimal treatment quality.Procrastination affect training engagement of an athletes?

Procrastination can indeed impact training engagement among athletes. Research has shown that procrastination levels among student athletes can vary, with some displaying moderate perfectionist tendencies and neutral procrastination behaviors. Furthermore, studies have highlighted the correlation between procrastination and personal characteristics like neuroticism, control over actions, and motivation for success in athletes participating in individual and team sports. Additionally, high procrastinating athletes have been found to exhibit deficits in proactive cognitive control, leading to increased attentional fluctuations and reduced engagement in proactive cognitive functions during tasks, which can affect training behavior. Therefore, addressing procrastination tendencies and promoting excellence-driven programs may enhance athletes' motivation and commitment to training, ultimately improving their performance and training engagement.How does vitamin C affect insulin resistance and glucose metabolism in individuals with diabetes?

Vitamin C supplementation has shown varying effects on insulin resistance and glucose metabolism in individuals with diabetes. Studies have indicated that vitamin C can lead to a reduction in serum hemoglobin A1c (HbA1c), fasting insulin, and fasting blood glucose levels in type 2 diabetes mellitus (T2DM) patients, especially with long-term and high-dose supplementation. Additionally, vitamin C has been associated with improvements in HbA1c and insulin resistance in diabetic populations, particularly in short-term interventions. While overall effects on glucose, HbA1c, and insulin concentrations have not been significant, subgroup analyses have shown that vitamin C can reduce glucose concentrations in patients with T2DM, older individuals, and with longer supplementation durations. Furthermore, vitamin C has demonstrated greater metabolic impacts on high-fat diet-induced metabolic dysregulation in genetically predisposed mice, emphasizing the importance of considering individual genetics and dietary patterns when utilizing vitamin C for managing diabetes.What is the evidence base for psychodynamic therapy?

The evidence base for psychodynamic therapy is substantial and growing, particularly in adult populations. Randomized Controlled Trials (RCTs) have been pivotal in evaluating psychodynamic psychotherapies (PDTs). Research indicates that PDTs are effective in treating various mental health issues, such as mood disorders, psychosomatic disorders, anxiety, and personality disorders. Additionally, psychodynamic therapy has been found to be cost-effective and comparable to other therapies in symptom improvement, while also excelling in addressing maladaptive interpersonal patterns. Studies focusing on children and adolescents have also shown promising results, especially in treating internalizing disorders like depression and anxiety, as well as emerging personality disorders and adversity-related issues. Despite the progress, further high-quality research, especially in the form of RCTs, is needed to enhance the understanding of psychodynamic psychotherapy's effectiveness in diverse populations.