How does the presence of DFI affect the odds of sucessful IVF?
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Elevated Sperm DNA Fragmentation Index (DFI) can significantly impact the success of in vitro fertilization (IVF) outcomes. Studies have shown that high DFI levels are associated with reduced rates of transplantable, high-quality embryos, implantation, clinical pregnancy, delivery, and live birth after IVF-ET, leading to an increased risk of early abortion per transfer cycle . However, when assisted by intracytoplasmic sperm injection (ICSI), the correlation between DFI and various IVF outcomes becomes insignificant . Additionally, in cases of total or partial fertilization failure during IVF, the sperm DFI can affect the fertilization rate, but ICSI can effectively remedy the situation, leading to successful outcomes . Therefore, managing and addressing elevated DFI levels through appropriate interventions like ICSI can optimize the chances of successful IVF outcomes.
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| Papers (5) | Insight |
|---|---|
| Raised sperm DNA Fragmentation Index (DFI) in men with Advanced Paternal Age negatively impacts IVF outcomes. Optimizing sperm selection methods like MACS, MF, or TESA can improve reproductive success. | |
Open access•Journal Article 3 Citations | Elevated Sperm DNA Fragmentation Index (DFI) can reduce the success rate of IVF/ICSI by impacting male fertility and increasing the likelihood of early spontaneous abortion. |
| Sperm DNA fragmentation index (DFI) influences the fertilization rate in rescue ICSI after partial fertilization failure, impacting the success of IVF treatments as a remedy. | |
| Elevated DNA fragmentation index (DFI) in sperm reduces the success rates of IVF by decreasing embryo quality, implantation, and pregnancy outcomes, increasing the risk of early abortion. | |
| In donor oocyte cycles, high sperm DNA fragmentation levels do not significantly impact IVF success rates, suggesting oocytes may repair sperm DNA damage during fertilization with ICSI. |
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