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How does thiamine deficiency affect the nervous system and cognitive function?

Thiamine pyrophosphate

Wernicke Encephalopathy

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Thiamine deficiency significantly impacts the nervous system and cognitive function. It can lead to various neurological manifestations, including Wernicke's encephalopathy, which is characterized by confusion, ataxia, and ocular abnormalities . Thiamine plays a crucial role in neurotransmitter synthesis and proper nerve function, and its deficiency can result in mitochondrial dysfunction, lactate accumulation, and focal thalamic degeneration, leading to cognitive decline . Studies have shown that thiamine deficiency contributes to synaptic dysfunction, reduced dendritic spine density, and impaired neurotransmission, which are closely linked to Alzheimer's disease pathogenesis and cognitive impairment . Therefore, maintaining adequate thiamine levels is essential for optimal nervous system function and cognitive health.

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Open access Vitamin B1 Thiamine Deficiency (Beriberi) Kimberly D. Wiley, Mohit Gupta - Show less +1 more 02 Jan 2019 7 Citations	Thiamine deficiency can impact the nervous system and cognitive function, leading to conditions like peripheral neuropathy, Wernicke-Korsakoff syndrome with gait changes, altered mental status, and ocular abnormalities.
Open access•Journal Article•DOI Thiamine deficiency contributes to synapse and neural circuit defects. Qiujian Yu, Huimin Liu, Shaoming Sang, Lulan Chen, Yingya Zhao, Yun Wang, Chunjiu Zhong - Show less +6 more 19 Sep 2018-Biological Research 14 Citations	Thiamine deficiency leads to synaptic dysfunction, reduced dendritic spine density, impaired neurotransmission, and cognitive decline, contributing to neural circuit defects and cognitive impairment in conditions like Alzheimer's disease.
Open access•Journal Article•DOI The importance of thiamine (vitamin B1) in humans. 30 Jun 2023-Bioscience Reports	Thiamine deficiency affects the nervous system by causing Wernicke's encephalopathy, leading to cognitive problems, confusion, and memory issues, potentially progressing to severe neurological complications.
Open access Vitamin B1 Thiamine Deficiency Kimberly D. Wiley, Mohit Gupta - Show less +1 more 21 Jun 2021 6 Citations	Thiamine deficiency can impact the nervous system and cognitive function, leading to conditions like peripheral neuropathy, Wernicke-Korsakoff syndrome with CNS symptoms, and altered mental status.
Open access•Journal Article•DOI A study of thiamine deficiency in patients with acute onsetencephalopathy Maleeha Anis Wani, Adil Bashir, Masood Tanvir, Sobia Nisar, Umair Altaf - Show less +4 more 31 May 2023-International journal of advanced research	Thiamine deficiency affects the nervous system by causing diverse clinical effects like encephalopathy, impacting cognitive function, leading to symptoms such as confusion, lethargy, and behavioral changes.

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