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How does ZMYND11 promote the spreading of histone posttranslational modificaitons?

RNA polymerase II

Transcription factor II D

RNA polymerase II holoenzyme

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ZMYND11, a candidate tumor suppressor, plays a crucial role in recognizing histone modifications, specifically H3K36 trimethylation on the histone variant H33, regulating transcription elongation. ZMYND11 acts as a 'reader' of these modifications, accumulating on gene bodies during transcription and modulating RNA polymerase II elongation. By recognizing H3K36me3 on H33, ZMYND11 influences the elongation stage of transcription, repressing a transcriptional program essential for tumor cell growth. Additionally, ZMYND11's occupancy in gene bodies requires the pre-deposition of H33K36me3, showcasing its specificity in recognizing and regulating histone modifications. This mechanism links histone variant-mediated transcription control to tumor suppression, highlighting ZMYND11's role in promoting the spreading of histone posttranslational modifications.

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Journal Article•DOI How Communication Between Nucleosomes Enables Spreading and Epigenetic Memory of Histone Modifications. Fabian Erdel 01 Dec 2017-BioEssays 24 Citations	Not addressed in the paper.
Open access•Journal Article•DOI ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression Hong Wen, Yuanyuan Li, Yuanxin Xi, Shiming Jiang, Sabrina A. Stratton, Danni Peng, Kaori Tanaka, Yongfeng Ren, Zheng Xia, Jun Wu, Bing Li, Michelle Craig Barton, Wei Li, Haitao Li, Xiaobing Shi - Show less +14 more 10 Apr 2014-Nature 277 Citations	ZMYND11 recognizes H3.3K36me3, aiding transcription elongation and tumor suppression by binding to H3.3 and H3K36me3, influencing gene expression and potentially impacting tumorigenesis.
Open access•Journal Article•DOI Nucleosome sliding can influence the spreading of histone modifications 16 Aug 2022-Physical Review E	Not addressed in the paper.
Open access•Posted Content•DOI Comprehensive pan-cancer in tumors of human with tumor suppressor ZMYND11 gene 29 Dec 2022	ZMYND11 inhibits tumor growth by reading histone proteins. It is under-expressed in most carcinomas and correlates with favorable prognosis in various cancers, impacting DNA methylation, gene alterations, and immune cell infiltration.
Open access•Posted Content Nucleosome sliding can influence the spreading of histone modifications. Shantanu Kadam, Tripti Bameta, Ranjith Padinhateeri - Show less +2 more 12 Oct 2021-arXiv: Biological Physics	Not addressed in the paper.

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